（1）表观遗传修饰酶相关调控剂的设计与合成
（2）抗肿瘤小分子化合物的合成与成药性评价

（1）国家自然科学基金委员会，面上项目，82473789，2025-01-01 至 2028-12-31，49万元，在研，主持
（2）国家自然科学基金委员会，面上项目，82173673，2022-01-01 至 2025-12-31，55万元，在研，结题
（3）江苏省自然科学基金委员会，优秀青年基金项目，BK20250202，2025-07-01 至 2028-06-31，50万元，主持，在研

1.Qiong Zhang, Yangguo Zhou, Jinglong Zhao, Lvbin Hu, Zhiwei Zhu, Huifang Wang, Yuhui Jin, Qidong You,* Zhengyu Jiang,* and Xiaoke Guo*, Discovery of 2Pyrazolylpyrimidinone Derivatives as New SPOP Inhibitors for Renal Cell Carcinoma Therapy, J. Med. Chem. 2025, 68, 14, 14945-14961.
2.Yabing Xin, Can Xiao, Nan Wang, Huidan Wu, Wenjing Kang, Xuetao Chen, Chihong Liu, Qidong You,* Zhengyu Jiang,* and Xiaoke Guo*, Rational Design of Novel Quinazolinone-Pyrrolodihydropyrrolone Analogs as PIM/HDAC Dual-Target Inhibitors for the Treatment of Acute Myelocytic Leukemia, J. Med. Chem. 2025, 68(11), 11062-11080.
3.Xuetao Chen, Tingting Wu, Yali Chen, Huidan Wu, Wenjing Kang, Nan Wang, Qidong You*, Xiaoke Guo*, and Zhengyu Jiang*, Supramolecular Host-Guest Assemblies for Tunable and Modular Lysosome-Targeting Protein Degradation, Angew. Chem. Int. Ed. 2025, e202506618.
4.Guanlu Long 1, Xianghan Wang 1, Xin Chen, Sai Ma, Liangkui Sun, Zhengyu Jiang*, Qidong You* and Xiaoke Guo*, Discovery of WDR5−MLL1 and HDAC Dual-Target Inhibitors for the Treatment of Acute Myeloid Leukemia, J. Med. Chem. 2025, 68, 1260−1279.
5.Wen-Long Fei, Ying-Zhe Wang, Qing-Lan Feng, Cui-Ting Li, Rui-Xin Jiang, Shi-Di Zhang, Yun Pan, Peng-Fei Ni, Fei-Ran Huang, Yi-Bing Huangfu, Shi-Da Zhang, Qi-Dong You **, Xiaoke Guo *, Discovery of the salicylaldehyde-based compound DDO-02267 as a lysine-targeting covalent inhibitor of ALKBH5, Eur. J. Med. Chem. 2025, 284, 117183.
6.Xian Zhang, Keni Cui, Xiaolu Wang, Yuanyuan Tong, Chihong Liu, Yuechao Zhu, Qidong You*, Zhengyu Jiang* and Xiaoke Guo*. Novel Hydrogen Sulfide Hybrid Derivatives of Keap1-Nrf2 Protein–Protein Interaction Inhibitor Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis, Antioxidants 2023, 12, 1062.
7.Hongyu Li, Qiong Zhang, Qinglan Feng, Qidong You* and Xiaoke Guo*. The development of small molecules targeting methyltransferase-like 3, Drug Discov. Today 2023, 28(4), 103513.
8.Yingzhe Wang1, Hongyu Li1, Yan Zhang, Ruixin Jiang, Jun Xu, Jing Gu, Zheng Jiang, Zhengyu Jiang,* Qidong You,* and Xiaoke Guo*, Discovery of Pyrazolo[1,5a]pyrimidine Derivative as a Novel and Selective ALKBH5 Inhibitor for the Treatment of AML, J. Med. Chem. 2023, 66(23), 15944−15959.
9.Weilin Chen, Xin Chen, Dongdong Li, Jianrui Zhou, Zhengyu Jiang*, Qidong You* and Xiaoke Guo*, Discovery of DDO-2213 as a Potent and Orally Bioavailable Inhibitor of the WDR5–Mixed Lineage Leukemia 1 Protein–Protein Interaction for the Treatment of MLL Fusion Leukemia, J. Med. Chem. 2021, 64(12), 8221-8245.
10.Xin Chen, Junjie Xu, Xianghan Wang, Guanlu Long, Qidong You* and Xiaoke Guo*, Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective, J. Med. Chem. 2021, 64(15), 10537-10556.