(1) 肝癌发病机制研究
(2) 非酒精性肝病发病机制研究
(3) 肝病关键靶点发现验证及药物筛选

1、科研项目
（1）国家自然科学基金青年项目：TADA2B调控肝癌细胞p53蛋白功能的作用机制及其三维结构稳定性研究，2020/01-2022/12，21万
（2）江苏省双创博士项目：肝细胞癌发病机制研究，2019/01-2022/12， 15万
（3）南京市留学人员科技创新项目：肝癌中p53蛋白功能异常调控机制研究, 2020/01-2022/12，3万
（4）重庆市自然科学基金面上项目，PORCN非Wnt底物发现及药物研究，2025.01-2027.12，10万
2. 科研奖励
欧洲肝病学会EASL青年科学家特别资助, EASL HCC SUMMIT , 2017

1. Yalin Zhang, Fengyu Ju , Li Yan, Xin Shen, Shiqing Guo, Muchen Yu, Yujia Cao , Wenhui Wang（王文辉）. Elevated Porcupine Disrupts Lipid Metabolism and Promotes Inflammatory Response in MASLD. Liver International, 2025, 45(4):e16130.（最后共同通讯作者）
2. Chang-Run Guo, Zhong-Zhe Zhang , Xing Zhou , Meng-Yang Sun, Tian-Tian Li, Yun-Tao Lei, Yu-Hao Gao, Qing-Quan Li, Chen-Xi Yue, Yu Gao, Yi-Yu Lin, Cui-Yun Hao, Chang-Zhu Li, Peng Cao, Michael X Zhu, Ming-Qiang Rong , Wen-Hui Wang（王文辉）, Ye Yu. Chronic cough relief by allosteric modulation of P2X3 without taste disturbance. Nature Communications, 2023, 14(1): 5844. （共同通讯作者）
3. Wenhui Wang （王文辉）, Pengyu Liu , Yalin Zhang , Li Yan, Michael X. Zhu, Jin Wang and Ye Yu. Expression and functions of transient receptor potential channels in liver diseases. Acta Pharmaceutica Sinica B, 2023, 13(2): 445-459. （共同第⼀作者，共同通讯作者）
4. Xuefei Ma, Tingting Wang, Wenhui Wang（王文辉）, Li Guan, Changrun Guo, Xinghua Li, Yuntao Lei, Yingzhe Fan, Xiaona Yang, Motoyuki Hattori, Osamu Nureki, Michael X Zhu, Ye Yu, Yun Tian, Jin Wang. The long β2,3-sheets encoded by redundant sequences play an integral role in the channel function of P2X7 receptors. Journal of Biological Chemistry, 2022, 298(6):102002. （共同第⼀作者）
5.Wenhui Wang（王文辉）, Pengyu Liu, Marla Lavrijsen, Shan Li, Ruyi Zhang, Shanshan Li, Wesley S van de Geer, Harmen J G van de Werken, Maikel P. Peppelenbosch, and Ron Smits. Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines. Scientific reports, 2021, 11(1):7470. （共同第⼀作者）
6.Wenhui Wang（王文辉）, Pengyu Liu, Kostandinos Sideras, Harmen J G van de Werken, Marieke van der Heide, Wanlu Cao, Marla Lavrijsen, Maikel P Peppelenbosch, Marco Bruno, Qiuwei Pan, Ron Smits. Oncogenic STRAP supports hepatocellular carcinoma growth by enhancing Wnt/β-catenin signaling. Molecular Cancer Research, 2019, 17(2):521-531. （唯⼀第⼀作者）
7.Wenhui Wang （王文辉）, Qiuwei Pan, Gwenny M. Fuhler, Ron Smits, and Maikel P. Peppelenbosch. Action and function of Wnt/β-catenin signaling in the progression from chronic hepatitis C to hepatocellular carcinoma. Journal of Gastroenterology, 2017, 52(4):419-431. （唯⼀第⼀作者，共同通讯作者）
8.Wenhui Wang（王文辉）, Lei Xu, Pengyu Liu, Kiran Jairam, Yuebang Yin, Kan Chen, Dave Sprengers, Maikel P. Peppelenbosch, Qiuwei Pan, Ron Smits. Blocking Wnt secretion reduces growth of hepatocellular carcinoma cell lines mostly independent of β-catenin signaling. Neoplasia, 2016, 18(12):711-723. （唯⼀第⼀作者）

硕士研究生
沈新（2023级）
居峰禹（2022级）