1、教育经历
(1) 2015/09–2022/06，中国药科大学，微生物与生化药学，理学博士
(2) 2011/09–2015/06，商丘师范学院，生物工程，学士
2、工作经历
(1) 2025/03 至 今，中国药科大学，药学院，副教授
(2) 2022/12–2024/02，南京医科大学，博士后
3、学术荣誉
2023年度国家资助博士后研究人员 B档资助
（1）蛋白质翻译后修饰与肿瘤发生发展
（2）肿瘤恶性演进分子机制研究
主持/参与科研项目
（1）国家自然科学基金委员会，青年科学基金项目（C类）[原青年科学基金项目]，82403111，TOX琥珀酸化修饰诱导I型固有淋巴细胞免疫耗竭促进肝癌进展的机制研究，2025.01至2027.12，30万，在研，主持。
（2）中国博士后科学基金，面上项目，2024M751488，TOX琥珀酸化修饰诱导I型固有淋巴细胞免疫耗竭促进肝癌进展的机制研究，2024.07至2026.06，8万元，在研，主持。
1.Xiaodong Li#, Yaning Fu#, Yalan Luo, Shuzhen Wang, Mengya Zhao*, Yijun Chen*, Oxidative modification of G-quadruplex triggers CLIC4-associated mitochondrial dysfunction to promote glioblastoma progression. Redox biology. 2025. (IF=11.9)
2.Mengya Zhao#, Yu Jin#, Zhongyi Yan#, Chunyan He#, Wenhua You, Zilong, Zhu, Ren, Wang, Yun Chen*, Yuan, Zhang* and Yao Yao*, The splicing factor QKI inhibits metastasis by modulating alternative splicing of E-Syt2 in papillary thyroid carcinoma. Cancer Letters. 2024; 604:217270. (IF=9.1)
3.Mengya Zhao#, Beiying Dai#, Xiaodong Li#, Yixin Zhang#, Chun Qiao, Yaru Qin, Zhao Li, Qingmei Li, Shuzhen Wang*, Yong Yang*, Yijun Chen*, RAPSYN-mediated meddylation of BCR-ABL alternatively determines the fate of philadelphia chromosome-positive leukemia, eLife. 2024; 12:RP88375. (IF=6.4) （Highlighted by eLife Digest）
4.Wenhua You#, Chupeng Hu#, Mengya Zhao#, Yuhan Zhang, Jinying Lu, Yedi Huang, Ling Li*, Yun Chen*, Extending inflamed-class signature to predict immune checkpoint inhibitor-based combination therapy in hepatocellular carcinoma. Gut. 2024; 0:1–3. (IF=23.0)
5.Mengya Zhao#, Xiaodong Li#, Yijun Chen*, Shuzhen Wang*, MD2 is a potential biomarker associated with immune cell Infiltration in gliomas. Frontiers in Oncology. 2022, 12: 854598. (IF=5.738)
6.Chupeng Hu#, Wenhua You#, Deyuan Kong, Yedi Huang, Jinying Lu, Mengya Zhao, Yu Jin, Rui Peng, Dong Hua, Dongming Kuang*, Yun Chen*. Tertiary lymphoid structure-associated B cells enhance CXCL13+CD103+CD8+ tissue-resident memory T-cell response to programmed cell death protein 1 blockade in cancer immunotherapy. Gastroenterology. 2024; 166:1069-1084. (IF=25.7)
7.Shuo Sun#, Shiyu Qian#, Ran wang#, Mengya Zhao, Ran Li, Wei Gu, Mengjie Zhao, Chunfa Qian, Liang Liu, Xianglong Tang, Yangyang Li, Hui Shi, Yunsong Pan, Hong Xiao, Kun Yang, Chupeng Hu, Yedi Huang, Liangnian Wei, Yuhan Zhang, Jing Ji*, Yun Chen*, Hongyi Liu*. Targeting GOLPH3L improves glioblastoma radiotherapy via regulating STING-NLRP3 mediated tumor immune microenvironment reprogramming. Science Translational Medicine. 2025; 17(788): eado0020. (IF=15.8)
