(1) 神经退行性疾病如阿尔茨海默病的药物新靶标发现与创新药物研究
(2) 精神疾病如抑郁症、焦虑症的药物新靶标发现与创新药物研究
(3) 药物成瘾性评价与机制研究

科研项目
（1）国家自然科学基金委员会, 面上项目, 82071202, 基底前脑胆碱能神经元TGR5在阿尔茨海默病中的作用及机制研究, 2021-01-01 至 2024-12-31, 55万元, 在研, 主持
（2）国家自然科学基金委员会, 青年科学基金项目, 81603113, R-9-(4氟苯基)-3-甲基-10,10,-二氢-6氢-苯并吡喃抗阿尔茨海默病的作用机制研究 , 2017-01-01 至 2019-12-31, 19万元, 结题, 主持
（3）江苏省科技厅，江苏省自然科学基金青年基金项目，BK20150705，基于雌激素受体调控作用探讨3-(p-甲苯基)-9-氢-氧杂蒽-9-酮抗糖尿病认知障碍的研究，2015-07-01 至 2018-06-30, 20万元, 结题, 主持

1.Chen F, Fang S, Du Y, Ghosh A, Reed MN, Long Y, Suppiramaniam V, Tang S*, Hong H*. CRISPR/Cas9-mediated CysLT1R deletion reverses synaptic failure, amyloidosis and cognitive impairment in APP/PS1 mice. Aging (Albany NY). 2021, 13(5):6634-6661. (IF: 5.955)
2.Chen F, Ghosh A, Lin J, Zhang C, Pan Y, Thakur A, Singh K, Hong H*, Tang S*. 5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential therapeutic targets for Alzheimer’s disease. Brain Behav Immun. 2020, 88: 844-855. (IF:7.217)
3.Tang SS*#, Ren Y#, Ren XQ, Cao JR, Hong H, Ji H, Hu QH*. ERα and/or ERβ activation ameliorates cognitive impairment, neurogenesis and apoptosis in type 2 diabetes mellitus mice. Exp Neuro. 2019, 311: 33-43. (IF: 5.33)
4.Chen F#, Yu XB#, Meng GL, Mei ZL, Du YF, Sun HB, Reed MN, Kong LY, Suppiramaniam V, Hong H*, Tang SS*. Hippocampal Genetic Knockdown of PPARδ Causes Depression-Like Behaviors and Neurogenesis Suppression. Int J Neuropsychopharmacol. 2019, 22 (6), 372-382. (IF:5.176)
5.Wu X, Lv YG, Du YF, Hu M, Reed MN, Long Y, Suppiramaniam V, Hong H*, Tang SS*. Inhibitory effect of INT-777 on lipopolysaccharide-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2019, 88:360-374. (IF: 5.067)
6.Wu X, Lv YG, Du YF, Chen F, Reed MN, Hu M, Suppiramaniam V, Tang SS*, Hong H*. Neuroprotective effects of INT-777 against Aβ1-42-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice. Brain Behav Immun. 2018, 73: 533-545. (IF: 6.17)
7.Tang SS*, Ren Y, Xu LJ, Cao JR, Hong H, Ji H, Hu QH*. Activation of ERα and/or ERβ ameliorates cognitive impairment and apoptosis in streptozotocin-induced diabetic mice. Horm Behav. 2018, 105: 95-103. (IF：4.418)
8.Wang H, Chen F, Du YF, Long Y, Reed MN, Hu M, Suppiramaniam V, Hong H*, Tang SS*. Targeted inhibition of RAGE reduces amyloid-β influx across the blood-brain barrier and improves cognitive deficits in db/db mice. Neuropharmacology. 2018, 131:143-153. (IF：4.367)
9.Li DD, Xie H, Du YF, Long Y, Reed MN, Hu M, Suppiramaniam V, Hong H*, Tang SS*. Antidepressant-like effect of zileuton is accompanied by hippocampal neuroinflammation reduction and CREB/BDNF upregulation in lipopolysaccharide-challenged mice. J Affect Disord. 2017, 227:672-680. (IF：3.786)
10.Tang SS, Hong H, Chen L, Mei ZL, Ji MJ, Xiang GQ, Li N, Ji H. Involvement of cysteinyl leukotriene receptor 1 in Aβ1-42-induced neurotoxicity in vitro and in vivo. Neurobiology of Aging. 2014, 35(3): 590-599.（IF: 5.013）

研究团队
洪浩 教授、唐苏苏 副教授、龙燕 副教授
穆荣豪 博士后

博士研究生：
李须逸（2019级）、陈志刚（2020级）、宋志鹏（2021级）
硕士研究生：
黄鑫（2020级）、聂睿哲（2021级）、章琪露 （2021级）、胡珊珊（2022级）、周欣婷（2022级）、江炜楷（2022级）