(1) 催化不对称合成
(2) 含硼、硅、氟生物活性分子设计合成
(3) 天然产物全合成

1、科研项目
（1）江苏省自然科学基金青年基金项目，BK20210414，活性聚酮类天然产物Disorazole家族的全合成、修饰改造研究，2021-07至2024-06，20万元，主持

1. Gao, S.;# Duan, M.;# Liu, J.; Yu, P.; Houk, K. N.;* Chen, M.* Stereochemical control via chirality pairing: stereodivergent syntheses of enantioenriched homoallylic alcohols. Angew. Chem. Int. Ed. 2021, 60, 24096. (IF = 15.336)
2. Gao, S.;# Liu, J.;# Chen, M.* Catalytic asymmetric transformations of racemic α-borylmethyl-(E)-crotylboronate via kinetic resolution or enantioconvergent reaction pathways. Chem. Sci. 2021, 12, 13398. (IF = 9.825)
3. Gao, S.;# Duan, M.;# Shao, Q.; Houk, K. N.;* Chen, M.* Development of α,α-disubstituted crotylboronate reagents and stereoselective crotylation via brønsted or Lewis acid catalysis. J. Am. Chem. Soc. 2020, 142, 18355. (IF = 15.419)
4. Gao, S.;# Duan, M.;# Houk, K. N.;* Chen, M.* Chiral phosphoric acid dual-function catalysis: asymmetric aldehyde allylation with α-vinyl allylboron reagent. Angew. Chem. Int. Ed. 2020, 59, 10540. (IF = 12.959)
5. Gao, S.; Chen, M.* Enantioselective syntheses of 1,4-pentadien-3-yl carbinols via Brønsted acid catalysis. Org. Lett. 2020, 22, 400. (IF = 6.091)
6. Gao, S.; Chen, M.* α-Silicon effect assisted Curtin–Hammett allylation using allylcopper reagents derived from 1,3-dienylsilanes. Chem. Sci. 2019, 10, 7554. (IF = 9.556)
7. Gao, S.;# Chen, J.;# Chen, M.* (Z)-α-Boryl-crotylboron reagents via Z-selective alkene isomerization and application to stereoselective syntheses of (E)-δ-boryl-syn-homoallylic alcohols. Chem. Sci. 2019, 10, 3637. (IF = 9.556)
8. Gao, S.; Chen, M.* Catalytic carboboration of dienylboronate for stereoselective synthesis of (E)-γ’,δ-bisboryl-anti-homoallylic alcohols. Chem. Commun. 2019, 55, 11199. (IF = 6.164)
9. Gao, S.; Chen, M.* Syntheses of unsymmetrical 1,4-bifunctional allylboron reagents via Cu-catalyzed highly regio- and stereoselective 1,4-protoboration of dienylboronates and analysis of the origin of chemoselective aldehyde syn-(hydroxymethyl)allylation. Org. Lett. 2018, 20, 7921. (IF = 6.492)
10. Gao, S.; Liu, H.; Wu, Z.; Yao, H.;* Lin, A.* Palladium-catalyzed allylic alkylation of pronucleophiles with alkynes to construct C-C and C-N bonds in water. Green Chem. 2017, 19, 1861. (IF = 9.125)