Faculty

  • Wanfeng Xu

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    Laboratory：
    • Biography
    Research directions
    Scientific research
    Scientific papers
    Research team

    1、 Educational Experience

    2015/09-2020/06, China Pharmaceutical University, Ph.D.

    2011/09-2015/06, China Pharmaceutical University, B.S.

    2、Working Experience

    2023/09- present, China Pharmaceutical University, Research fellow.

    2020/08-2023/08, China Pharmaceutical University-Shenzhen Luohu Hospital, post-doctor.

    1. Natural Science Foundation of China (82304590), “Mechanism of GSDME-mediated pyroptosis in chemotherapy-induced liver failure and drug intervention research”, Role: PI, 01/01/2024-12/31/2026, RMB 300,000.

    2.Shenzhen Science and Technology Innovation Commission, Basic Research General Program (JCYJ20220530151415034), “Mechanism of GSDME in the process of drug-induced liver failure”, Role: PI, 10/01/2022-10/01/2025, RMB 150,000.

    3. Guangdong Medical Science and Technology Research Foundation (A2023228),“Pharmacological mechanisms of gasdermins inhibitors on acute liver failure“, Role: PI, 07/01/2023-06/30/2025, RMB 10,000.



    1.Wanfeng Xu; Yuan Che; Quan Zhang; Hai Huang; Chujie Ding; Yun Wang; Guangji Wang; Lijuan Cao; Haiping Hao; Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition, Cell Metabolism, 2021, 33(2): 424-436.

    2. Wanfeng Xu; Yun Wang; Shuang Cui; Qiuling Zheng; Yanghao Lin; Qingqing Cui; Yuxin Xie; Yuming Zeng; Chuan Zhang; Yujie Li; Xin Jin; Minna Qin; Huiyong Sun; Haiping Hao; Lijuan Cao; Methylcobalamin protects against liver failure via engaging gasdermin E, Nature Communications, 2025, 16(1): 1233.

    3.Yuan Che; Wanfeng Xu; Chujie Ding; Tianyu He; Xiaowei Xu; Yubing Shuai; Hai Huang; Jiawei Wu; Yun Wang; Chen Wang; Guangji Wang; Lijuan Cao; Haiping Hao; Bile acids target mitofusin 2 to differentially regulate innate immunity in physiological versus cholestatic conditions, Cell Reports, 2023, 42(1): 112011.

    4.Wanfeng Xu; Quan Zhang; Chujie Ding; Huiyong Sun; Yuan Che; Hai Huang; Yun Wang; Jiawei Wu; Haiping Hao; Lijuan Cao; Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure, Acta Pharmacologica Sinica, 2021, 42(1): 68-76.

    5.Wanfeng Xu; Yun Wang; Hai Huang; Jiawei Wu; Yuan Che; Chujie Ding; Quan Zhang; Weiling Cao; Lijuan Cao; Octreotide-based therapies effectively protect mice from acute and chronic gastritis, European Journal of Pharmacology, 2022, 928: 174976.