(1)Development and industrialization of particulate preparations;

(2)Sustained/controlled release and quick-release preparations;

(3)Innovative nasal preparation and transdermal drug delivery systems.

1. Research Projects

(1) National Ten Thousand People Program, Young Top-ranking Talents, 2022-10 to Now, 1,800,000 yuan, In Progress, Host;

(2) National Natural Science Foundation of China, 82073401, 2021-01 to 2024-12, 550,000 yuan, In Progress, Host; 

(3) School-enterprise joint project, Epidermal immunotherapy preparations, 2022-05 to 2027-12, 1,050,000 yuan, In Progress, Host;

(4) School-enterprise joint project, Spray preparations, 2021-03 to 2025-12, 1,500,000 yuan, In Progress, Host; 

(5) State Key Laboratory of Efficacy and Utilization of Medicinal Plants Open Project Fund, [2022] 387, 2022-01 to 2024-01, 200,000 Yuan, In Progress, Host;

(6) National Science and Technology Key Project of The Key New Drugs Creation, 2017ZX09101-001, 2017-01 to 2020-12, 1,330,000 yuan, Completed, Host;

(7) National Pharmacopoeia Commission, National Pharmaceutical Standards Improvement Project, ZG2017-4-01, 2017-09 to 2018-12, 1,000,000 yuan, Completed, Host;

(8) National Pharmacopoeia Commission, National Pharmaceutical Standards Improvement Project, 2017-001, Guiding Principles and General Principles of Particulate Preparations, 2017-09 to 2019-12, 1,000,000 yuan, Completed, Host;

(9) National Natural Science Foundation of China, Youth Science Foundation of National Natural Science Foundation of China, 81501582, 2016-01 to 2018-12, 216,000 yuan, Completed, Host;

(10) Jiangsu Provincial Science and Technology Department, Jiangsu Provincial Natural Science Foundation, BK20171390, 2017-07 to 2020-06, 100,000 yuan, Completed, Host.

2. Academic Awards

(1) Jiangsu Provincial Science and Technology Department, Jiangsu Provincial Science and Technology Second Prize, 2019 (2/7)

(2) Ministry of Education, Scientific Research Award of Higher Education, 2023 (5/6)

(3) Youth Pharmacy Award, Chinese Pharmaceutical Association, 2016 (1/1)

(4) Young Star of Science and Technology, Nanjing Pharmaceutical Association, 2019(1/1)

(5) Travel Award, American Association of Pharmaceutical Scientists, 2018 (1/1)

3. Representative Research Achievements

(1) Establish the key technology of biomimetic recombination of natural particles and efficient self-assembly drug delivery system to solve the bottleneck of hypotonic transport of insoluble drugs and improved the clinical efficacy.

(2) Reveal the regulation mechanism of bionic transmembrane transport of natural particles to solve the difficult problem of complex physiological membrane barrier delivery of biological macromolecules.

(3) Develop multidimensional prevention and treatment strategies for Alzheimer's disease based on biomimetic HDL recombination technology, and further elucidate the interventional mechanism of HDL in neurodegenerative diseases.

1.Han, G.#; Bai, K.#; Yang, X.; Sun, C.; Ji, Yi.; Zhou, J.*; Zhang, H.*; Ding, Y.* “Drug-Carrier” Synergy Therapy for Amyloid-β Clearance and Inhibition of Tau Phosphorylation via Biomimetic Lipid Nanocomposite Assembly. Adv. Sci. 2022, 9(14): e2106072, Doi: 10.1002/advs.202106072. (IF: 17.521)

2.Wang, R.; Wang, X.; Li, J.; Di, L.; Zhou, J.*; Ding, Y.*, Lipoprotein-biomimetic nanostructure enables tumor-targeted penetration delivery for enhanced photo-gene therapy towards glioma. Bioact Mater 2022, 13: 286-299, Doi: 10.1016/j.bioactmat. (IF: 16.874)

3.Zhang, H.#; Jiang, W.#; Zhao, Y. #; Song, T.; Xi, Y.; Han, G.; Jin, Y.; Song, M.; Bai, K.; Zhou, J.*; Ding, Y.*, Lipoprotein-Inspired Nanoscavenger for the Three-Pronged Modulation of Microglia-Derived Neuroinflammation in Alzheimer's Disease Therapy. Nano Lett. 2022, 22 (6): 2450-2460, Doi: 10.1021/acs.nanolett.2c00191 (IF: 12.262)

4.Wang, Z.#; Ding, B.#; Zhao, Y.; Han, Y.; Sheng, Y.; Tao, L.; Shen, X.; Zhou, J.*; Jiang, L.; Ding, Y.*, Tumor-oriented mathematical models in hydrogel regulation for precise topical administration regimens. J. Control. Release 2022, 345: 610-624, Doi: 10.1016/j.jconrel.2022.03.042 (IF: 11.467)

5.Cheng, H.; Jiang Z.; Sun, C.; Wang Z.; Han, G.; Chen X.; Li T.; Fan Z.; Zhang F.; Yang X.; Lv L.; Zhang, H.*; Zhou, J.*; Ding, Y.* Protein stabilized polymeric nanoparticles inspired relay drug delivery for tackling post-chemotherapeutic metastasis. Chem. Eng. J. 2022, 427: 131672, Doi: 10.1016/j.cej.2021.131672 (IF: 16.744)

6.Wang, Z.; Cheng, H.; Sheng, Y.; Chen, Z.; Zhu, X.; Ren, J.; Zhang, X.; Lv, L.; Zhang, H.; Zhou, J.*; Ding, Y.*, Biofunctionalized graphene oxide nanosheet for amplifying antitumor therapy: Multimodal high drug encapsulation, prolonged hyperthermal window, and deep-site burst drug release. Biomaterials 2022, 287: 121629, Doi: 10.1016/j.biomaterials.2022.121629 (IF: 15.304)

7. Zhang, H.#; Jin, Y.#; Chi, C.#; Han, G.#; Jiang, W.#; Wang, Z.; Cheng, H.; Zhang, C.; Wang, G.; Sun, C.; Chen, Y.; Xi, Y.; Liu, M.; Gao, X.; Lin, X.; Lv, L.; Zhou, J.*; Ding, Y.*, Sponge particulates for biomedical applications: Biofunctionalization, multi-drug shielding, and theranostic applications. Biomaterials 2021, 273: 12082, Doi: 10.1016/j.biomaterials.2021.120824 (IF: 15.304)

8.Zhang, H.#; Cheng, H.#; Han, Y.; Jin, Y.; Wang, G.; Sun, C.; Jiang, W.; Han, G.; Sun, B.; Jiang, Z.; Yuan, Z.; Zhou, J.*; Ding, Y.*, Natural discoidal lipoproteins with tiny modification for tumor extracellular dissociation in antitumor chemoimmunotherapy. Biomaterials 2021, 275: 120859, Doi: 10.1016/j.biomaterials.2021.120859(IF: 15.304)

10.Cheng, H.#; Zhang, H. #; Xu, G.; Peng, J.; Wang, Z.; Sun, B.; Aouameur, D.; Fan, Z.; Jiang, W.; Zhou, J.*; Ding, Y.*, A Combinative Assembly Strategy Inspired Reversibly Borate-Bridged Polymeric Micelles for Lesion-Specific Rapid Release of Anti-Coccidial Drugs. Nano-micro Lett 2020, 12 (1), 155, Doi: 10.1007/s40820-020-00495-1 (IF: 23.655)

Professor: Ding Yang, Zhou Jianping

Associate Professor: Zhang Huaqing

Postdoctoral Fellow: Cheng Hao