Research direction is bioanalysis. The purpose is to develop analytical method for in vivo/in vitro determination of drugs and their biomarkers for drug quality and safety assurance.

1. Research Projects

(1) National Natural Science Foundation of China (82173954): 2022.1-2025.12

(2) National Natural Science Foundation of China (81573557): 2016.1-2019.12

(3) National Natural Science Foundation of China (81274064): 2013.1-2016.12

2. Academic Awards

2007  Jiangsu Science and Technology Progress Award (4 / 6, Jiangsu Provincial People's Government)

3. Representative Research Achievements

(1) Sensitive and specific analytical methods for multiple types of genotoxic impurities in drugs, including common genotoxic or potential genotoxic impurities.

(2)A cell model with SERS sensing technology has been developed for toxicity assessment on genotoxic or potential genotoxic impurities in drugs.

(3)The improving of drug quality standards for traditional Chinese medicines. Some analytical methods such as assay, impurity test and identification of metabolites have been established for R&D of traditional Chinese medicine.

1. Han, L. F.; Huang, X. X.; Zhu, H. T.; Wang, R. Y.; Zhao, B.; Liu, S. X.; Li, Q.; Qian, W. X.; Feng, F.; Liu, F. L.; Xue, J. W.; Liu, W. Y., Programmed cyclodextrin-based core–shell nanoparticles for cooperative TGF-β blockade to reverse immunosuppression post photodynamic therapy. Chem Eng J .2023, 455, 140830. (IF 16.744)

2. Zhang, Y. Q; Hou, S. Y.; Song, H. L.; Qin, G. W.; Li, P. Q.; Zhang, K. D.; Li, T. F.; Han, L. F.; Liu, W. Y.; Ji, S. L., A green and facile one-step hydration method based on ZIF-8-PDA to prepare melamine composite sponges with excellent hydrophobicity for oil-water separation. J Hazard Mater. 2023, 451, 131064. (IF 14.224)

3. Zhang, Z. T.; Zhang, K. X.; Wang, R. Y.; Zhu, J. X.; Xue, J. W.; Liu, F. L.; Chi, H.;  Yang, H. J.; Feng, F.; Liu, W. Y.; Qu, W., A self-amplified necrotic targeting theranostic nanoparticle with deep tumor penetration for imaging-guided personalized chemo-photodynamic therapy. Chem Eng J .2023, 455, 140465. (IF 16.744)

4. Li, Q.; Chen, Y.; Xing, S. S.; Liao, Q. H.; Xiong, B. C.; Wang, Y. Y.; Lu, W. X.; He, S. Y.; Feng, F.; Liu, W. Y.; Chen, Y.; Sun, H. P., Highly potent and selective butyrylcholinesterase Inhibitors for cognitive improvement and neuroprotection. J Med Chem. 2021, 64 (10), 6856-6876. (IF 7.446)

5. Liu, F. F.; Zhao, X. P.; Liao, X. W.; Liu, W. Y.; Chen, Y. M.; Wang, C., Ultrasensitive and label-free detection of cell surface glycan using nanochannel-Ionchannel hybrid coupled with electrochemical detector. Anal Chem. 2020,92(7), 5509-5516. (IF 6.986)

Wenyuan Liu：Professor

Feng Zheng：Professor

Jing Liu：Associate Professor

Wenting Liao：Associate Professor

Lingfei Han：Lecturer