1. Research Projects
(1)Study of the mechanisms of cinnabar-induced central neurotoxicity based on the Metallomics of mercury (Grant Number: 81903911), supported by National Natural Science Foundation of China, 2020-2022.
(2)Study of the central neurotoxicity of Cinnabaris based on the Metallomics (Grant Number: BK20190556), supported by Natural Science Foundation of Jiangsu Province, 2019- .
(3)Study on the toxicity and safety of Cinnabaris-containing TCM Baizi Yangxin Pill based on the mercury speciation analysis (Grant Number: 2017M621885), supported by China Postdoctoral Science Foundation, 2017-2020.
2. Representative Research Achievements
(1)Impurity analysis is one of the key and difficult points in drug quality control. Based on the modern analytical techniques including HRMS, NMR, a drug impurity research strategy has been established. It has helped a series of manufacturers to optimize the production process and improve the quality of API and pharmaceutics such as flumazenil and zopiclone.
(2)Cinnabar (HgS) is a mercury-containing traditional Chinese material medica with potential toxicity. Our group studied on the mechanisms of the cinnabar-induced central neurotoxicity through the Metallomics and Lipidomics methods. Combined with the results of LA-ICP-MS in situ imaging of mercury in rat’s brain, HPLC-CV-AFS mercuric species, LC-HRMS lipid analysis, the material basis and the mechanisms of cinnabar-induced central neurotoxicity were revealed, which can provide scientific references for the safety evaluation and rational use of cinnabar.
Metallomics, Lipidomics, Assessment of drug quality and safety, Study on the material basis and mechanisms of TCMs
1. Research Projects
(1)Study of the mechanisms of cinnabar-induced central neurotoxicity based on the Metallomics of mercury (Grant Number: 81903911), supported by National Natural Science Foundation of China, 2020-2022.
(2)Study of the central neurotoxicity of Cinnabaris based on the Metallomics (Grant Number: BK20190556), supported by Natural Science Foundation of Jiangsu Province, 2019- .
(3)Study on the toxicity and safety of Cinnabaris-containing TCM Baizi Yangxin Pill based on the mercury speciation analysis (Grant Number: 2017M621885), supported by China Postdoctoral Science Foundation, 2017-2020.
2. Representative Research Achievements
(1)Impurity analysis is one of the key and difficult points in drug quality control. Based on the modern analytical techniques including HRMS, NMR, a drug impurity research strategy has been established. It has helped a series of manufacturers to optimize the production process and improve the quality of API and pharmaceutics such as flumazenil and zopiclone.
(2)Cinnabar (HgS) is a mercury-containing traditional Chinese material medica with potential toxicity. Our group studied on the mechanisms of the cinnabar-induced central neurotoxicity through the Metallomics and Lipidomics methods. Combined with the results of LA-ICP-MS in situ imaging of mercury in rat’s brain, HPLC-CV-AFS mercuric species, LC-HRMS lipid analysis, the material basis and the mechanisms of cinnabar-induced central neurotoxicity were revealed, which can provide scientific references for the safety evaluation and rational use of cinnabar.
1. Wu W.; Cheng R.; Boucetta H.; Xu L.; Pan J.R.; Song M.; Lu, Y.T.*; Hang, T.J.*. Differences in Multicomponent Pharmacokinetics, Tissue Distribution, and Excretion of Tripterygium Glycosides Tablets in Normal and Adriamycin-Induced Nephrotic Syndrome Rat Models and Correlations with Efficacy and Hepatotoxicity. Front. Pharmacol. 2022, 13, 910923. (IF: 5.988)
2. Jiang, J.; Hu, Z.L.; Boucetta, H.; Liu, J.M.; Song, M.; Hang, T.J.*; Lu, Y.T.* Identification of degradation products in flumazenil using LC-Q-TOF/MS and NMR: Degradation pathway elucidation. J. Pharm. Biomed. Anal. 2022, 12;215:114764. (IF: 3.571)
3. Xu, L.; Wang, Y.; Wu, D.F.; Sun, F.M.; Di, B.; Xu, H.; Song, M.; Lu, Y.T.*; Hang, T.J.* Identification and monitoring of fentanyls-related substances in east China sewage water samples by LC-MS for drug enforcement. Sci Total Environ. 2021, 797:149109. (IF:7.963)
4. Han, X.; Cheng, F.J.; Di, B.; Xu, H.; Song, M.; Hang, T.J.*; Lu, Y.T.* Identification and characterization of new impurities in zopiclone tablets by LC-QTOF-MS. J. Pharm. Biomed. Anal. 2021, 199:114056. (IF: 3.935)
5. Lu, Y.T.; Hu, Z.L.; Shao, F.X.; Song, M. Hang, T.J.* Simultaneous determination of tazarotene, clindamycin phosphate and their active metabolites in Bama mini-pig skin by LC-MS/MS: Application to the development of a tazarotene/clindamycin phosphate cream techniques. J. Chromatogr. B 2021, 1162:122455. (IF: 3.205)
6. Lu, Y.T.; Guan, R.; Zheng, J.R.; Hang, T.J.*; Song, M.* Determination of clobetasol propionate, tazarotene and tazarotenic acid in Bama mini-pig skin by UPLC-MS/MS: Application to pharmacokinetic and drug-drug interaction studies. J. Pharm. Biomed. Anal. 2020, 186, 113322. (IF: 3.209)
7. Lu, Y.T.; Qi, W.Z.; Wang, S.; Song, X.N.; Yang, D.Y.; Song, M.; Hang, T.J.* Toxicity and risk assessment of mercury exposures from cinnabar and Baizi Yangxin Pills based on pharmacokinetic and tissue distribution studies. J Ethnopharmacol. 2020, 250, 112489. (IF: 4.360)
8. Lu, Y.T.; Chen, Y.F.; Qi, W.Z.; Song, M.*; Hang, T.J.* Separation and identification of process-related substances and degradation products in mycophenolate mofetil by LC-QTOF mass spectrometric method. J. Sep. Sci. 2019, 42(16):2650-2659. (IF: 2.878)
9. Lu, Y.T.; Sun, X.Y.; Song, F.; Wang, L.; Song, M.; Hang, T.J.* Impurity profiling of varenicline tartrate by LC-QTOF mass spectrometric techniques during drug development. J. Pharm. Biomed. Anal. 2018, 155: 306-313. (IF: 2.983)
10. Lu, Y.T.; Yang, D.Y.; Song, X.N.; Wang, S.; Song, M.; Hang, T.J.* Bioaccessibility and health risk assessment of mercury in cinnabar containing Traditional Chinese Medicines. J. Trace Elem. Med. Bio. 2017, 44: 17-25. (IF: 3.755)
