1.Pharmacodynamic material basis and herb-drug interaction

2.Pathogenesis of Alzheimer’s Disease

1. Research Projects

(1)Zhejiang Provincial Public Security Department, Project of Urban Sewage Drug Abuse Assessment，2020.01~2022.12，2608000 yuan，in charge.
(2)Zhejiang Provincial Public Security Department, Project of Urban Sewage Drug Abuse Assessment，2018.01~2019.12，870000 yuan，in charge.
(3)National Natural Science Foundation，No. 81673678，Study on the mechanism of toxicity reduction and efficacy enhancement of Danggui buxue tang and gemcitabine combination in the treatment of NSCLC based on metabolic enzymes regulation，2017.01~2020.12，560000 yuan，in charge.

(4)National Natural Science Foundation，No. 81001619，Pharmacodynamic material basis and compatibility mechanism study of Ermiao Pills based on metabonomics and multi-component pharmacokinetics，2011.01~2013.12，200000 yuan，in charge.

(5)National Key R&D Program of China (Grant No. 2017YFC0803606 and 2018YFC0807400)，Research on drug crime disposal and drug rehabilitation technology and equipment，2018.01~2021.12，375000 yuan，Sub-project leader.

2. Representative Research Achievement

(1)NSFC funded project ‘Study on the mechanism of toxicity reduction and efficacy enhancement of Danggui buxue tang and gemcitabine combination in the treatment of NSCLC based on metabolic enzymes regulation’ found that after combined use of Danggui buxue decoction, the concentration of gemcitabine active metabolites in PBMCs increased significantly. Danggui buxue decoction can regulate the expression of dCK, P-gp, HuR and Nrf2 in tumor tissue, and play an antitumor synergistic role. At the same time, Danggui buxue decoction can improve the organ index, the number of white blood cells and platelets, the expression levels of TPO, GM-CSF, IL-2 and IL-6, up-regulate the expressions of cyclin D1, CDK4 and CDK6. And it also can relieve the G1 phase of BMNCs in model mice, promoting the proliferation of BMNCs, and then reduce myelosuppression.

(2)‘Project of Urban Sewage Drug Abuse Assessment’ in Zhejiang province carried out from 2018~2022 drew a sewage drug abuse map for 11 cities 118 sampling sites characterized with abuse level and species. 

1.Huo, Y. T.; Xu, K.H.; Lu, Y.T.; Ma, L. M.; Zhou, C.L.; Hang, T.J.; Song, M.* Characterization of structurally related peptide impurities using HPLC-QTOF-MS/MS: application to Cbf-14, a novel antimicrobial peptide. Anal. Bioanal. Chem. 2022; https://doi.org/10.1007/s00216-022-04205-1 (IF: 4.478)

2.Liu, Y.; Chang, M.; Hu, Z.L.; Xu, X.; Wu, W.; Ning, M.R.; Hang, T.J.*; Song, M.* Danggui Buxue Decoction enhances the anticancer activity of gemcitabine and alleviates gemcitabine-induced myelosuppression. J. Ethnopharmacol. 2021; 273: 113965 (IF: 5.195)

3.Lu, Y.T.; Hu, Z.L.; Shao, F.X.; Song, M.; Hang, T.J.* Simultaneous determination of tazarotene, clindamycin phosphate and their active metabolites in Bama mini-pig skin by LC-MS/MS: Application to the development of a tazarotene/clindamycin phosphate cream. J Chromatogr. B 2021; 1162: 122455 (IF: 3.318)

4.Xu, L.; Wang, Y.; Wu, D.f.; Sun, F.M.; Di, B.; Xu, H.; Song, M.; Lu, Y.T.*; Hang, T.J.* Identification and monitoring of fentanyls-related substances in east China sewage water samples by LC-MS for drug enforcement. Sci. Total Environ. 2021; 797:149109. (IF: 10.753)

5.Han, X.; Cheng, F.J.; Di, B.; Xu, H.; Song, M.; Hang, T.J.*; Lu, Y.T.* Identification and characterization of new impurities in zopiclone tablets by LC-QTOF-MS. J Pharm. Biomed. Anal. 2021; 199: 114056. (IF: 3.571)

6.Lu, Y.T.; Guan, R.; Zheng, J.R.; Hang, T.J.*; Song, M.* Determination of clobetasol propionate, tazarotene and tazarotenic acid in Bama mini-pig skin by UPLC-MS/MS: Application to pharmacokinetic and drug-drug interaction studies. J Pharm. Biomed. Anal. 2020; 186: 113322. (IF: 3.571)

7.Wu, X.; Guan, R.; Liu, Y.X.; Wu, S.H.; Song, M.*; Hang, T.J.* Comparative health risk assessment of realgar and NiuHuangJieDu tablets based on tissue arsenic levels after multiple oral administration to rats. J. Ethnopharmacol. 2020; 249: 112370. (IF: 5.195)

8.Sun, X.Y.; Xu, X.; Chen, Y.F.; Guan, R.; Cheng, T.T.; Wang, Y.; Jin, R.; Song, M.*; Hang, T.J.* Danggui Buxue Decoction Sensitizes the Response of Non-Small-Cell Lung Cancer to Gemcitabine via Regulating Deoxycytidine Kinase and P-glycoprotein. Molecule. 2019; 24: 2011. (IF: 4.927)

9.Wu, X.; Wu, S.H.; Liu, Y.X.; Guan, R.; Liang, F.M.; Song, M.*; Hang, T.J.* Health risk assessment of arsenic in Realgar and NiuHuangJieDu Tablets based on pharmacokinetic study. J Trace Elem. Med. Bio. 2018; 48: 81-86. (IF: 3.995)

10.Wu, X.; Zeng, X.F.; Wang, L.; Hang, T.J.; Song, M.* Identification of related substances in tofacitinib citrate by hyphenated techniques for synthetic process optimization, J Pharm. Biomed. Anal. 2017; 143: 17-25. (IF: 3.571)

Hang Taijun, Professor

Lu Yuting, Associate professor

Ji Shunli, Associate professor

PhD students：

Zhang Pei (2019), Xu Xin (2019), Zhan Xiang (2020), Wang Xiang(2021)

Postgraduate students:

Chen Hanqing, Tang Tian, Zhao Wenrui, Jiang Zhenzhen, Lin Lingxiang, Wu Mengying, Liu Jiaying (2022)

Liu Yan, Yang Jixue, Zhou Yue, Jin Xin, Fu Yahui, Wen Minghao, Li Wenqi, Yin Zixuan, Wu Jiawei (2021)

Xu Kehui, Zheng Yuting, Qin Wanning, Hong Tao, Gu Mengyao, Yang Huili, Zhang Tingyi (2020)