(1)Application of novel materials and technologies in proteomics analysis and drug analysis;

(2)Application of proteomic and metabolomic technologies in research of Chinese traditional medicine action and drug addiction mechanism;

(3)Application of modern analytical technology in research of drug quality evaluation.

1.Research Projects

(1)National Natural Science Foundation of China, Grant No.82173956,Based on IDO1-mediated ‘metabolism-immunity’ crosstalk network in malignant transformation of non-resolving inflammation investigation of material basis and mechanisms of panax notoginseng saponins, 01/01/2022 – 12/31/2025, PI

(2)Natural Science Foundation of Jiangsu, Grant No. SBK2014022061, A Label-free Quantitative approach based on LC-MS/MS of the mechanism research of metadherin as drug-resistant target in human chronic myeloid leukemia , 01/07/2014 – 01/07/2017, PI

(3)National Natural Science Foundation of China,  Grant No. 2016ZZD008, A Label-free Quantitative approach based on LC-MS/MS of the mechanism research of metadherin as drug-resistant target in human chronic myeloid leukemia, 01/01/2013 – 12/31/2015, PI

1.Gao, L.; Tao, J.; Qi, L.K. ; Jiang, X.Y. ; Shi, H.F.; Liu, Y.H.; Di, B.*; Wang, Y.J.* ; Yan, F.* Synthesis of a metal oxide affinity chromatography magnetic mesoporous nanomaterial and development of a one-step selective phosphopeptide enrichment strategy for analysis of phosphorylated proteins. Anal Chim Acta, 2022, 1195: 339430. (IF: 6.911)

2.Qi, L.K.; Dong, T.; Jiang, X.Y.; Li, J.J.; Di, B.*; Yan, F*. Preparation of polydopamine-functionalized mesoporous silica-coated core/shell magnetic nanocomposite for efficiently extracting five amphetamine-type stimulants from wastewater followed by UPLC-MS/MS determination. J Hazard Mater, 2022, 426: 128082. (IF: 14.224)

3.Qi, L.K. ; Jiang, X.Y.; Wu, N. ; Li, J.J. ; Di, B. *; Yan, F.* Synthesis of a novel polydopamine and C18 dual-functionalized magnetic core-shell mesoporous nanocomposite for enrichment and analysis of widely abused illegal drugs in urine samples on site and in the laboratory. J Pharmaceut Biomed, 2022，212：114556 (IF: 3.935)

4.Li, X.M.; Yuan, D.Y.; Liu, Y.H.; Zhu, L.; Qin, H.K.; Yang, Y.B.; Li, Y. ; Yan, F.*; Wang, Y.J.* Panax notoginseng saponins prevent colitis-associated colorectal cancer via inhibition IDO1 mediated immune regulation. Chin J Nat Medicines，2022, 20, 258 (IF: 3.887)

5.Yan F.; Liu G.; Chen T.; Fu X.; Niu M.M.* Structure Based Virtual Screening and Biological Evaluation of Peptide Inhibitors for Polo-Box Domain. Molecules, 2019, 25, 107 (IF: 4.411)

6.Yang, D.S.; Ding, X.Y.; Min, H.P.; Li, B.; Su, M.X.; Niu, M.M.; Di, B.*; Yan, F.* Design and synthesis of an immobilized metal affinity chromatography and metal oxide affinity chromatography hybrid material for improved phosphopeptide enrichment. Journal of Chromatography A, 2017, 1505: 56 (IF: 3.716)