1. Research Projects
(1) General Program of the National Natural Science Foundation of China, 82174051, Research on the Effects and Mechanisms of Total Glucosides of Paeonia Alba and Its Components in Regulating the Differentiation and Migration of Intestinal Mucosal Immune CD4+Th17 Cells in the Treatment of Sjogren's Syndrome, 2022/01-2024/12.
(2) General Program of the National Natural Science Foundation of China, 81673434, Research on the Role and Mechanism of GPR40 Receptors in the Pathogenesis and Treatment of Alzheimer's Disease, 2017/01-2020/12.
(3) National Natural Science Foundation of China, 81670425, Research on the Role and Mechanism of STAT1 in Regulating Vascular Smooth Muscle Cell Phenotype in Atherosclerosis, 2017/01-2019/12.
(4) General Project of the National Natural Science Foundation of China, 81573494, Exploring the Effect of the Microenvironment Nuclear Receptor Metabolic Enzyme Axis on Drug Metabolic Disposition and Its Molecular Mechanism Based on the Liver Cancer Spherical Cell Model, 2016/01-2018/12.
(5) Key Program of the National Natural Science Foundation of China, 81430091, Research on the Theory and Methodology of Three dimensional Pharmacodynamic Material Basis of Traditional Chinese Medicine in vivo, 2015/01-2019/12.
(6) General Program of the National Natural Science Foundation of China, 81473151, Research on the Construction and Quantitative Integration of a Multivariate Drug Release System Based on Deconvolution Principle and Chronological Administration Synchronization of the Main Components of Salvia miltiorrhiza in vivo, 2015/01-2017/12.
(7) Youth Program of National Natural Science Foundation of China, 81403000, Research on Mechanism of Salvia Miltiorrhiza and Panax Notoginseng Reversing Aspirin Resistance Based on Salicylic Acid Accumulation Arachidonic Acid Metabolism Network, 2015/01-2017/12.
(8) General Program of the National Natural Science Foundation of China, 81374054, Study on the Brain Protection Mechanism of Panax Notoginseng Saponin Mediated by Intestinal Microflora and Its PK-PD Binding, 2014/01-2016/12.
2. Academic Awards
(1) 2012,Podium Presentation Award of AAPS-NUS 7th PharmSci@Asia Symposium，No.1
(2) 2022,First Prize in Translation Competition for Language Service of The Belt and Road Initiative，No.1
3. Representative Research Achievements
The metabolic research of traditional Chinese medicine has been faced with headaches such as complex components, unclear action processes, massive detection data, difficult to eliminate noise, lack of standard reference, and inability to determine effective ingredients. In order to establish a scientific methodology for data processing and data mining,，this study developed a strategy to rapidly screen and identify the ophiopogonins in Ophiopogon extracts as a model drug. We developed and validated a chemicalome to metabolome matching approach(CMMA) by taking ginsenoside extract as an example to delineate the metabolic networks of complex systems. We also developed and validated a chemicalome to metabolome matching approach by taking herbal medicine as an example to delineate the metabolic networks of complex systems.
(1) Study on Pharmacokinetics and Pharmacodynamics of Multicomponents of Traditional Chinese Medicine
(2) Pharmacological Research on Immune System Network
(3) Cardiovascular Pharmacology Research
1. Research Projects
(1) General Program of the National Natural Science Foundation of China, 82174051, Research on the Effects and Mechanisms of Total Glucosides of Paeonia Alba and Its Components in Regulating the Differentiation and Migration of Intestinal Mucosal Immune CD4+Th17 Cells in the Treatment of Sjogren's Syndrome, 2022/01-2024/12.
(2) General Program of the National Natural Science Foundation of China, 81673434, Research on the Role and Mechanism of GPR40 Receptors in the Pathogenesis and Treatment of Alzheimer's Disease, 2017/01-2020/12.
(3) National Natural Science Foundation of China, 81670425, Research on the Role and Mechanism of STAT1 in Regulating Vascular Smooth Muscle Cell Phenotype in Atherosclerosis, 2017/01-2019/12.
(4) General Project of the National Natural Science Foundation of China, 81573494, Exploring the Effect of the Microenvironment Nuclear Receptor Metabolic Enzyme Axis on Drug Metabolic Disposition and Its Molecular Mechanism Based on the Liver Cancer Spherical Cell Model, 2016/01-2018/12.
(5) Key Program of the National Natural Science Foundation of China, 81430091, Research on the Theory and Methodology of Three dimensional Pharmacodynamic Material Basis of Traditional Chinese Medicine in vivo, 2015/01-2019/12.
(6) General Program of the National Natural Science Foundation of China, 81473151, Research on the Construction and Quantitative Integration of a Multivariate Drug Release System Based on Deconvolution Principle and Chronological Administration Synchronization of the Main Components of Salvia miltiorrhiza in vivo, 2015/01-2017/12.
(7) Youth Program of National Natural Science Foundation of China, 81403000, Research on Mechanism of Salvia Miltiorrhiza and Panax Notoginseng Reversing Aspirin Resistance Based on Salicylic Acid Accumulation Arachidonic Acid Metabolism Network, 2015/01-2017/12.
(8) General Program of the National Natural Science Foundation of China, 81374054, Study on the Brain Protection Mechanism of Panax Notoginseng Saponin Mediated by Intestinal Microflora and Its PK-PD Binding, 2014/01-2016/12.
2. Academic Awards
(1) 2012,Podium Presentation Award of AAPS-NUS 7th PharmSci@Asia Symposium，No.1
(2) 2022,First Prize in Translation Competition for Language Service of The Belt and Road Initiative，No.1
3. Representative Research Achievements
The metabolic research of traditional Chinese medicine has been faced with headaches such as complex components, unclear action processes, massive detection data, difficult to eliminate noise, lack of standard reference, and inability to determine effective ingredients. In order to establish a scientific methodology for data processing and data mining,，this study developed a strategy to rapidly screen and identify the ophiopogonins in Ophiopogon extracts as a model drug. We developed and validated a chemicalome to metabolome matching approach(CMMA) by taking ginsenoside extract as an example to delineate the metabolic networks of complex systems. We also developed and validated a chemicalome to metabolome matching approach by taking herbal medicine as an example to delineate the metabolic networks of complex systems.
1. Wu,L; Gong, P.; Wu,Y.Z; Liao,K; Shen,H.Y; Qi,Q; Liu,H.Y; Wang,G.J*; Hao,H.P*. An integral strategy toward the rapid identification of analogous nontarget compounds from complex mixtures. Journal of Chromatography. A. 2013, 16(1303): 39-47 (IF: 4.326)
2. Wu,L; Wu,Y.Z; Shen,H.Y; Gong, P.; Cao,L.J; Wang,G.J*; Hao,H.P*. Quantitative structure–ion intensity relationship strategy to the prediction of absolute levels without authentic standards. Analytica Chimica Acta. 2013, 794(10): 67-75 (IF: 5.418)
3. Gong, P.; Cui,N; Wu,L; Liang,Y; Hao,K; Xu,X.Y; Tang,W.G; Wang,G.J*; Hao,H.P*. Chemicalome and metabolome matching approach to elucidating biological metabolic networks of complex mixtures. Analytical Chemistry. 2012, 84(6): 2995-3002 (IF: 6.713)
4. Hao,K.; Gong, P.; Sun,S.Q.; Hao,H.P.; Wang,G.J.*; Dai,Y.; Chen,Y.C; Liang,Y.; Xie,L.; Li,F.Y; Li,H.Y. Mechanism-based pharmacokinetic-pharmacodynamic modeling of the estrogen-like effect of ginsenoside Rb1 on neural 5-HT in ovariectomized mice. European Journal of Pharmaceutical Science. 2011, 44 (1-2), 117-126. (IF: 4.227)
5. Hao,K.; Gong, P.; Sun,S.Q.; Hao,H.P.; Wang,G.J.*; Dai,Y.; Liang,Y.; Xie,L.; Li,F.Y. Beneficial estrogen-like effects of ginsenoside Rb1, an active component of Panax ginseng, on neural 5-HT disposition and behavioral tasks in ovariectomized mice. European Journal of Pharmaceutical Science. 2011, 659(1):15-25. (IF: 4.227)
He Ling（Professor），Chen Tong，Sun Yi，Xing Mengtao
