Epigenetic regulation and drug screening in liver disease.

1.Research Projects

Natural Science Foundation of China (82200684), “Regulation of liver regeneration by ubiquitin E3 ligase Peli1”, Role: PI, 01/01/2023-12/31/2025, RMB 300,000.

Natural Science Foundation of Jiangsu Province (SBK2022044783), “Regulation of liver regeneration by lysine demethylase PHF2”, Role: PI, 07/01/2022-06/30/2025, RMB 200,000.

2.Academic Awards

Hainan Provincial Science and Technology Progress Award, 2021. 3^rd.

National Graduate Student Scholarship, 2020.

3.Representative Research Achievements

The application of chitin in the preparation of drugs for preventing and treating heart disease.

Application of MK571 in the preparation of drugs for the treatment and prevention of heart diseases.

The Application of Reversan in the Preparation of Drugs for the Treatment and Prevention of Heart Disease.

1. Li, N.; Liu, H.; Xue, Y.; Xu, Z.; Miao, X.; Guo, Y.; Li, Z.; Fan, Z.; Xu, Y. Targetable Brg1-CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking. EMBO Mol Med 2023, 15 (3), e16592. DOI: 10.15252/emmm.202216592. IF: 14.26

2. Kong, M.; Dong, W.; Kang, A.; Kuai, Y.; Xu, T.; Fan, Z.; Shi, L.; Sun, D.; Lu, Y.; Li, Z.; et al. Regulatory role and translational potential of CCL11 in liver fibrosis. Hepatology 2023. DOI: 10.1097/HEP.0000000000000287. IF: 17.298

3. Dong, W.; Kong, M.; Liu, H.; Xue, Y.; Li, Z.; Wang, Y.; Xu, Y. Myocardin-related transcription factor A drives ROS-fueled expansion of hepatic stellate cells by regulating p38-MAPK signalling. Clin Transl Med 2022, 12 (2), e688. DOI: 10.1002/ctm2.688. IF: 8.554

4. Li, Z.; Zhao, Q.; Lu, Y.; Zhang, Y.; Li, L.; Li, M.; Chen, X.; Sun, D.; Duan, Y.; Xu, Y. DDIT4 S-Nitrosylation Aids p38-MAPK Signaling Complex Assembly to Promote Hepatic Reactive Oxygen Species Production. Adv Sci (Weinh) 2021, 8 (18), e2101957. DOI: 10.1002/advs.202101957. IF: 17.521

5. Li, Z.; Zhang, Y.; Zhang, Y.; Yu, L.; Xiao, B.; Li, T.; Kong, X.; Xu, Y. Corrigendum: BRG1 Stimulates Endothelial Derived Alarmin MRP8 to Promote Macrophage Infiltration in an Animal Model of Cardiac Hypertrophy. Front Cell Dev Biol 2021, 9, 650029. DOI: 10.3389/fcell.2021.650029. IF: 6.081

6. Kong, M.; Dong, W.; Zhu, Y.; Fan, Z.; Miao, X.; Guo, Y.; Li, C.; Duan, Y.; Lu, Y.; Li, Z.; et al. Redox-sensitive activation of CCL7 by BRG1 in hepatocytes during liver injury. Redox Biol 2021, 46, 102079. DOI: 10.1016/j.redox.2021.102079. IF: 10.787

7. Li, Z.; Zhang, Y.; Zhang, Y.; Yu, L.; Xiao, B.; Li, T.; Kong, X.; Xu, Y. BRG1 Stimulates Endothelial Derived Alarmin MRP8 to Promote Macrophage Infiltration in an Animal Model of Cardiac Hypertrophy. Front Cell Dev Biol 2020, 8, 569. DOI: 10.3389/fcell.2020.00569. IF: 6.081

8. Li, Z.; Kong, X.; Zhang, Y.; Zhang, Y.; Yu, L.; Guo, J.; Xu, Y. Dual roles of chromatin remodeling protein BRG1 in angiotensin II-induced endothelial-mesenchymal transition. Cell Death Dis 2020, 11 (7), 549. DOI: 10.1038/s41419-020-02744-y. IF: 9.685

9. Li, Z.; Lv, F.; Dai, C.; Wang, Q.; Jiang, C.; Fang, M.; Xu, Y. Activation of Galectin-3 (LGALS3) Transcription by Injurious Stimuli in the Liver Is Commonly Mediated by BRG1. Front Cell Dev Biol 2019, 7, 310. DOI: 10.3389/fcell.2019.00310. IF: 6.081

10. Li, Z.; Chen, B.; Dong, W.; Kong, M.; Fan, Z.; Yu, L.; Wu, D.; Lu, J.; Xu, Y. MKL1 promotes endothelial-to-mesenchymal transition and liver fibrosis by activating TWIST1 transcription. Cell Death Dis 2019, 10 (12), 899. DOI: 10.1038/s41419-019-2101-4. IF: 9.685

Xu Yong, Professor.

Li Zilong, Associate Professor