Nucleic acid drug transfection and delivery.

1.Representative Research Achievements

(1) High-loading and controlled-release vector technology of biomacromolecules and their active complexes was created to improve therapeutic efficacy of gene intervention.

(2) Timing-controlled drug delivery system against microenvironment gradient was created for the programmed delivery of biomacromolecule and chemical drugs to tackle invasion, migration and immunosuppression in clinical oncotherapy.

1. Cheng, H.; Jiang, Z. J.; Sun, C. K.; Wang, Z.; Han, G. C.; Chen, X.; Li, T. Y.; Fan, Z. C.; Zhang, F.; Yang, X. Y.; Lv, L. Y.; Zhang, H. Q.; Zhou, J. P.; Ding, Y.*, Protein stabilized polymeric nanoparticles inspired relay drug delivery for tackling post-chemotherapeutic metastasis. Chem Eng J, 2022, 427, 131672. (IF: 16.744)

2. Zhang, H. Q.; Cheng, H.; Han, Y.; Jin, Y.; Wang, G.; Sun, C. H.; Jiang, W. X.; Han, G. C.; Sun, B.; Jiang, Z. J.; Yuan, Z.; Zhou, J. P.*; Ding, Y.*, Natural discoidal lipoproteins with tiny modification for tumor extracellular dissociation in antitumor chemoimmunotherapy. Biomaterials, 2021, 275, 120859. (IF: 15.304)

3. Cheng, H.; Zhang, F.; Ding, Y.*, CRISPR/Cas9 Delivery System Engineering for Genome Editing in Therapeutic Applications. Pharmaceutics, 2021, 13 (10), 1649. (IF: 6.525)

4. Cheng, H.; Zhang, H. Q.; Xu, G. J.; Peng, J.; Wang, Z.; Sun, B.; Aouameur, D.; Fan, Z. C.; Jiang, W. X.; Zhou, J. P.*; Ding, Y.*, A Combinative Assembly Strategy Inspired Reversibly Borate-Bridged Polymeric Micelles for Lesion-Specific Rapid Release of Anti-Coccidial Drugs. Nano-Micro Lett, 2020, 12 (1), 155. (IF: 16.419)

5. Aouameur, D.; Cheng, H.; Opoku-Damoah, Y.; Sun, B.; Dong, Q. L.; Han, Y.; Zhou, J. P.*; Ding, Y.*, Stimuli-responsive gel-micelles with flexible modulation of drug release for maximized antitumor efficacy. Nano Res, 2018, 11(8), 4245-4264. (IF: 8.515)