(1) In vivo visualization of nano drugs

(2) Visualization technology of oral solid preparation

(3) Research and development of novel slow and controlled release preparations

1.Research Projects

(1) National Natural Science Foundation of China, Grant No. 82204291, Visualization of the in vivo fate of nanocrystalline drugs based on intrinsic organic room-temperature phosphorescence, 2023-01 to 2025-12, ¥300,000, In progress, Principal Investigator

(2) China Postdoctoral Science Foundation, Grant No. 2021M703597, In vivo spatial and temporal fate of drug nanocrystals, 2021-11 to 2023-1, ¥80,000, In progress, Principal Investigator

(3) Jiangsu Funding Program for Excellent Postdoctoral Talent, Grant No. 2022ZB300, Molecular imaging guided in vivo fate of drug crystals and its application in disease diagnosis and treatment, 2022-07 to 2024-07, ¥300,000, In progress, Principal Investigator

1.Xu, M.; Long, W.; Ling, X.; Hu, X.; Hong, H.; Peng, Y.^*; Cai, T.^*, Multifunctional theragnostic ultrasmall gold nanodot-encapsuled perfluorocarbon nanodroplets for laser-focused ultrasound sequence irradiation (LFSI)-based enhanced tumor ablation. Journal of Materials Chemistry B 2022, 10 (47), 9816-9829. (IF: 7.571)

2.Peng, Y.; Cong, Y.; Lei, Y.; Sun, F.; Xu, M.; Zhang, J.; Fang, L.; Hong, H.^*; Cai, T.^* Transforming passive into active: Multimodal pheophytin-based carbon dots customize protein corona to target metastatic breast cancer. Adv. Healthc. Mater. 2022, 11, 2102270. (IF: 11.092)

3.Sun, F.^†; Peng, Y.^†; Li, Y.; Xu, M.; Cai, T.^* Fenton-reaction-triggered metabolism of acetaminophen for enhanced cancer therapy. Chin. Chem. Lett. 2022. (IF: 8.455)

4.Chen, J.; Guo, M.; Fan, R.; Peng, Y.; Cai, T.^* Impact of bile salt on solution-mediated phase transformation of pharmaceutical cocrystals: The importance of coformer release kinetics. Chem. Eng. J. 2022, 435, 134928. (IF: 16.744)

5.Peng, Y.; Ye, C.; Yan, R.; Lei, Y.; Ye, D.; Hong, H.; Cai, T.^* Activatable core-shell metallofullerene: An efficient nanoplatform for bimodal sensing of glutathione. ACS Appl. Mater. Inter. 2019, 11, (50), 46637-46644. (IF: 10.383)

6.Huang, S.; Xu, J.; Peng, Y.; Guo, M.; Cai, T.^* Facile tuning of the photoluminescence and dissolution properties of phloretin through cocrystallization. Cryst. Growth & Des. 2019, 19, (12), 6837-6844. (IF: 4.010)

7.Zhang, J.; Shi, Q.; Tao, J.; Peng, Y.; Cai, T.^* Impact of polymer enrichment at the crystal-liquid interface on crystallization kinetics of amorphous solid dispersions. Mol. Pharmaceut. 2019, 16, (3), 1385-1396. (IF: 5.364)

8.Peng, Y.; Yang, D.; Lu, W.; Hu, X.; Hong, H.^*; Cai, T.^* Positron emission tomography (PET) guided glioblastoma targeting by a fullerene-based nanoplatform with fast renal clearance. Acta Biomater. 2017, 61, 193-203. (IF: 10.633)