(1) 肿瘤靶点相关的小分子药物设计、合成与作用机理解析
(2) 医用高分子的设计合成与药物分子的靶向递送
(3) 低维有机纳米材料的表面合成与性质研究
课题组网页：
https://www.x-mol.com/groups/liu_pn1

已发表SCI论文130余篇。近5年，以通讯作者发表SCI论文39篇（其中IF>10：19篇），包括J. Am. Chem. Soc（5篇）、Angew. Chem. Int. Ed.（3篇）、Nat. Commun.（2篇）、Natl. Sci. Rev.（1篇）、Adv. Mater.（1篇）、Sci. Adv.（1篇）等；并申请中国发明专利23项，授权6项。已主持国家自然科学基金项目8项和省部级项目8项，参与国家自然科学基金重大项目1项和创新研究群体项目1项。

1.Q.-H. Xu, X.-Y. Yin, Z.-Q. Chen, E.-K. Huang, X. Yao,* X. Li,* P.-N. Liu*, Construction of In Situ Personalized Cancer Vaccines by Bioorthogonal Catalytic Microneedles for Augmented Melanoma Immunotherapy, Small 2025, 21, 2500015.
2.X. Li,* M.-L. Gao, S.-S. Wang, Y.-L. Li, T.-N. Liu, H. Xiang,* P.-N. Liu*, Engineering an Organic Nanoplatform for Augmented Pyroeletroimmunotherapy, Adv. Mater. 2024, 36, 2400756. 
3.X. Li*, M.-L. Gao, S.-S. Wang, Y. Hu, D. Hou, P.-N. Liu*, H. Xiang*, Nanoscale covalent organic framework-mediated pyroelectrocatalytic activation of immunogenic cell death for potent immunotherapy, Sci. Adv. 2024, 10, eadr5145. 
4.Deng-Yuan Li,* Yuqiang Zheng, Ricardo Ortiz,* B.-X. Wang, Y. Jiang, B. Yuan, X.-Y. Zhang, C. Li, L. Liu, X. Liu, D. Guan, Y. Li, H. Zheng, C. Liu, J. Jia, T. Frederiksen, P.-N. Liu*, S. Wang*, Magnetic exchange interaction between unpaired π- and d-electrons in nanographene-metal coordination complexes, Natl. Sci. Rev. 2025, 12, nwaf033. 
5.Z. Yuan, X.-Y. Zhang, Y. Jiang, X. Qian, Y. Wang, Y. Liu, L. Liu, X. Liu, D. Guan, Y. Li, H. Zheng, C. Liu, J. Jia, M. Qin,* P.-N. Liu,* D.-Y. Li*, S. Wang*, Fractional Spinon Quasiparticles in Open-Shell Triangulene Spin-1/2 Chains, J. Am. Chem. Soc. 2025, 147, 5004-5013. 
6.X. Li*, X.-Z. Wang, B. Shen, Q.-Y. Chen, H. Xiang, P. Yu*, P.-N. Liu*, Organocatalyzed diastereo- and enantioselective synthesis of N-N atropisomeric isoindolinones bearing central chirality, Nat. Commun. 2025, 16, 1662. 
7.D.-Y. Li*, Z.-Y. Huang, L.-X. Kang, B.-X. Wang, J.-H. Fu, Y. Wang, G.-Y. Xing, Y. Zhao, X.-Y. Zhang, P.-N. Liu*, Room-temperature selective cyclodehydrogenation on Au(111) via radical addition of open-shell resonance structures, Nat. Commun. 2024, 15, 9545. 
8.Y. Wang, W.-W. Gong, Y. Zhao, G.-Y. Xing, L.-X. Kang, F. Sha, Z.-Y. Huang, J.-W. Liu, Y.-J. Han, P. Li, D.-Y. Li,* P.-N. Liu*, Two-Dimensional Nonbenzenoid Heteroacene Crystals Synthesized via In-Situ Embedding of Ladder Bipyrazinylenes on Au(111), Angew. Chem. Int. Ed. 2024, 63, e202318142. 
9.J.-W. Liu, Y. Wang, L.-X. Kang, Y. Zhao, G.-Y. Xing, Z.-Y. Huang, Y.-C. Zhu, D.-Y. Li*, P.-N. Liu*, Two-Dimensional Crystal Transition from Radialene to Cumulene on Ag(111) via Retro-[2+1] Cycloaddition, J. Am. Chem. Soc. 2023, 145, 13048.
10.G. Zhu, Y. Jiang, Y. Wang, B.-X. Wang,  Y. Zheng, Y. Liu, L.-X. Kang, Z. Li, D. Guan, Y. Li, H. Zheng, C. Liu, J. Jia, T. Lin, P.-N. Liu*, D.-Y. Li*, S. Wang*, Collective Quantum Magnetism in Nitrogen-Doped Nanographenes, J. Am. Chem. Soc. 2023. 145, 7136.
11.D.-Y. Li,* Y. Wang, X.-Y. Hou, Y.-T. Ren, L.-X. Kang, F.-H. Xue, Y.-C. Zhu, J.-W. Liu, M. Liu*, X.-Q. Shi*, X. Qiu*, P.-N. Liu*, On-Surface Synthesis of [3]Radialenes via [1+1+1] Cycloaddition, Angew. Chem. Int. Ed. 2022, 61, e202117714.

刘培念 教授（博导，兴药杰出科学家）
李登远 教授（博导，兴药领军学者）
蒋炜 副教授
江露露 博士后
赵志文 博士后

本团队拥有充足事业编制用人指标，长期招聘药物化学（含CADD和AIDD设计、小分子药物、多肽药物、ADC偶联药物等）和药剂学（含药物缓释、靶向递送、佐剂开发和生物医用材料等方向）等研究方向特聘研究员、副教授、特聘副研究员、博士后！

学术博士招生专业：药物化学
专业博士招生专业：生物与医药-制药工程
学术硕士招生专业：药物化学、化学（理学院）
专业硕士招生专业：药学-药物合成与工艺优化