(1) 肝肠疾病药物靶标发现和确证研究
(2) 中草药治疗肝肠疾病作用和机理研究

1.学术获奖
NIH: Fellows Award for Research Excellence (FARE) competition, 2022, 排名1/1
NCI/CCR: Travel Award- Outstanding Oral Presentation, 2023，排名1/1
Acta Pharmaceutica Sinica B: 2021 High Impact Paper Award, 2021, 排名1/1
NIH: Outstanding GPP Graduation Research Award, 2016, 排名1/1
2.代表性科研成果
(1) 揭示肠PPARα-FABP1轴、肝PPARα与CYP2E1和Let-7交互调控、肝CEBPα-OPN轴等内源性代谢信号通路调控肝病进展的新作用和机理
(2) 揭示吴茱萸、圣约翰草、南非醉茄等草药或其活性成分改善肝肠疾病的新作用和/或机理，且部分草药研究进入合作转化开发协商阶段。
(3)“反向药代”研究揭示代谢处置影响甘草酸在不同肝病中的药效发挥

(1) Yan T, Yan N, Xia Y, Sawaswong V, Zhu X, Dias HB, Aibara D, Takahashi S, Hamada K, Saito Y, Li G, Liu H, Yan H, Velenosi TJ, Krausz KW, Huang J, Kimura S, Rotman Y, Qu A*, Hao H*, Gonzalez FJ*. Hepatocyte-specific CCAAT/enhancer binding protein α restricts liver fibrosis progression. J Clin Invest, 2024, 134(7):e166731 (IF=15.9)
(2) Yan T#, Luo Y#, Yan N, Hamada K, Zhao N, Xia Y, Wang P, Zhao C, Qi D, Yang S, Sun L, Cai J, Wang Q, Jiang C, Gavrilova O, Krausz KW, Patel DP, Yu X, Wu X, Hao H, Liu W*, Qu A*, Gonzalez FJ*. Intestinal peroxisome proliferator-activated receptor α-fatty acid-binding protein 1 axis modulates nonalcoholic steatohepatitis. Hepatology, 2023, 77(1):239-255 (IF=13.5)
(3) Zhang Y#, Yan T#*, Wang T, Liu X, Hamada K, Sun D, Sun Y, Yang Y, Wang J, Takahashi S, Wang Q, Krausz KW, Jiang C, Xie C, Yang X*, Gonzalez FJ*. Crosstalk between CYP2E1 and PPARα substrates and agonists modulate adipose browning and obesity. Acta Pharm Sin B, 2022, 12(5):2224-2238 (IF=14.5)
(4) Hamada K#, Wang P#, Xia Y#, Yan N, Takahashi S, Krausz KW, Hao H, Yan T*, Gonzalez FJ*. Withaferin A alleviates ethanol-induced liver injury by inhibiting hepatic lipogenesis. Food Chem Toxicol, 2022, 160:112807 (IF=4.3)
(5) Yan T#, Luo Y#, Xia Y, Hamada K, Wang Q, Yan N, Krausz KW, Ward JM, Hao H, Wang P*, Gonzalez FJ*. St. John's Wort alleviates dextran sodium sulfate-induced colitis through pregnane X receptor-dependent NFκB antagonism. FASEB J, 2021, 35(11):e21968 (IF=5.8)
(6) Yagai T#, Yan T#, Luo Y#, Takahashi S, Aibara D, Kim D, Brocker CN, Levi M, Motohashi H, Gonzalez FJ*. Feedback repression of PPARα signaling by Let-7 microRNA. Cell Rep, 2021, 36(6):109506 (IF=10.0)
(7) Yan T#, Yan N#, Wang H, Yagai T, Luo Y, Takahashi S, Zhao M, Krausz KW, Wang G*, Hao H*, Gonzalez FJ*. FXR-Deoxycholic Acid-TNF-α Axis Modulates Acetaminophen-Induced Hepatotoxicity. Toxicol Sci, 2021, 181(2):273-284 (IF=4.1)
(8) Xia Y#, Wang P#, Yan N, Gonzalez FJ*, Yan T*. Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3. Cell Death Dis, 2021, 12(2):174 (IF=9.7)
(9) Zhang Y#, Yan T#, Sun D, Xie C, Wang T, Liu X, Wang J, Wang Q, Luo Y, Wang P, Yagai T, Krausz KW, Yang X*, Gonzalez FJ*. Rutaecarpine inhibits KEAP1-NRF2 interaction to activate NRF2 and ameliorate dextran sulfate sodium-induced colitis. Free Radic Biol Med, 2020, 148:33-41 (IF=8.1)
(10) Yan T*, Yan N, Wang P, Xia Y, Hao H, Wang G, Gonzalez FJ*. Herbal drug discovery for the treatment of nonalcoholic fatty liver disease. Acta Pharm Sin B, 2020, 10(1):3-18 (IF=11.6)

课题组长
颜婷婷 教授
博士研究生
颜娜娜(2021级)
代梦格 （2024级）
硕士研究生
聂亮亮(2024级)
杨颖 （2024级）