（1）表观遗传修饰酶相关调控剂的设计与合成
（2）抗肿瘤小分子化合物的合成与成药性评价

（1）国家自然科学基金委员会，面上项目，82473789，基于KH3/4假二聚体虎钳构象发现、设计m6A阅读蛋白IGF2BP2的变构抑制剂并探索其在急性白血病中的应用，2025-01-01 至 2028-12-31，49万元，在研，主持
（2）国家自然科学基金委员会，面上项目，82173673，基于靶标结构设计、合成高选择性ALKBH5抑制剂并探索其在肿瘤疾病中的应用，2022-01-01 至 2025-12-31，55万元，在研，主持
（3）国家自然科学基金委员会，面上项目，81872799，通过构象调控方法设计MLL1-WDR5蛋白-蛋白相互作用小分子抑制剂并探索其在血液肿瘤中的应用，2019-01-01 至 2022-12-31，57万元，结题，主持
（4）国家自然科学基金委员会，青年基金，81502915 全新骨架组蛋白甲基转移酶G9a抑制剂的构效关系、结合模式及作用机制研究，2015-01-01 至 2018-12-31，21.28万元，结题，主持
（5）江苏省自然科学基金委员会，面上项目，BK20191321，新型靶向MLL1-WDR5治疗血液肿瘤的小分子抑制剂的设计、合成及生物学研究，2019-07-01 至 2022-06-31，10万元，结题，主持

1.Xian Zhang, Mengjie Ye, Yuxin Ge, Can Xiao, Keni Cui, Qidong You*, Zhengyu Jiang* and Xiaoke Guo*, A Spatiotemporally Controlled and Mitochondria-Targeted Prodrug of Hydrogen Sulfide Enables Mild Mitochondrial Uncoupling for the Prevention of Lipid Deposition, J. Med. Chem. 2024, 67, 21, 19188–19199.
2.Sai Ma, Guanlu Long, Zheng Jiang, Yan Zhang, Liangkui Sun, Yun Pan, Qidong You*, Xiaoke Guo*, Recent advances in targeting histone H3 lysine 36 methyltransferases for cancer therapy, Eur. J. Med. Chem. 2024, 274, 116532.
3.Xuetao Chen 1, Tingting Wu 1, Zhiyan Du 1, Wenjing Kang, Rujun Xu, Fanying Meng, Chihong Liu, Yali Chen, Qichao Bao, Jingkang Shen, Qidong You, Danyan Cao***, Zhengyu Jiang **, Xiaoke Guo *, Discovery of a brain-permeable bromodomain and extra terminal domain (BET) inhibitor with selectivity for BD1 for the treatment of multiple sclerosis, Eur. J. Med. Chem. 2024, 265, 116080.
4.Yuanqian Cai, Yingzhe Wang, Bingjie Mao, Qidong You **, Xiaoke Guo*. Targeting insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) for the treatment of cancer, Eur. J. Med. Chem. 2024, 268, 116241.
5.Yingzhe Wang1, Hongyu Li1, Yan Zhang, Ruixin Jiang, Jun Xu, Jing Gu, Zheng Jiang, Zhengyu Jiang,* Qidong You,* and Xiaoke Guo*, Discovery of Pyrazolo[1,5a]pyrimidine Derivative as a Novel and Selective ALKBH5 Inhibitor for the Treatment of AML, J. Med. Chem. 2023, 66(23), 15944−15959.
6.Xian Zhang, Keni Cui, Xiaolu Wang, Yuanyuan Tong, Chihong Liu, Yuechao Zhu, Qidong You*, Zhengyu Jiang* and Xiaoke Guo*. Novel Hydrogen Sulfide Hybrid Derivatives of Keap1-Nrf2 Protein–Protein Interaction Inhibitor Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis, Antioxidants 2023, 12, 1062.
7.Hongyu Li, Qiong Zhang, Qinglan Feng, Qidong You* and Xiaoke Guo*. The development of small molecules targeting methyltransferase-like 3, Drug Discov. Today 2023, 28(4), 103513.
8.Lingyue Zhao, Qian Yang , Yiqun Tang, Qidong You* and Xiaoke Guo*, Design, synthesis, and biological evaluation of arylmethylpiperidines as Kv1.5 potassium channel inhibitors, J. Enzym. Inhib. Med. Chem. 2022, 37(1), 462-471.
9.Weilin Chen, Xin Chen, Dongdong Li, Jianrui Zhou, Zhengyu Jiang*, Qidong You* and Xiaoke Guo*, Discovery of DDO-2213 as a Potent and Orally Bioavailable Inhibitor of the WDR5–Mixed Lineage Leukemia 1 Protein–Protein Interaction for the Treatment of MLL Fusion Leukemia, J. Med. Chem. 2021, 64(12), 8221-8245.
10.Xin Chen, Junjie Xu, Xianghan Wang, Guanlu Long, Qidong You* and Xiaoke Guo*, Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective, J. Med. Chem. 2021, 64(15), 10537-10556.