1、教育经历
(1) 2012/09–2018/01， 中国科学院上海有机化学研究所，生命有机国家重点实验室，理学博士 （导师：汤文军研究员）
(2) 2008/09–2012/07， 郑州大学，化学学院，学士 （导师：杨贯羽教授，汤文军研究员）
2、工作经历
(1) 2025/01 至今， 中国药科大学，药学院，教授
(2) 2020/10–2024/06， 美国加州大学圣塔芭芭拉分校，化学与生物化学系，博士后（合作导师：Yang Yang教授）
(3) 2018/04–2020/10，美国夏威夷大学癌症中心、美国夏威夷大学马诺阿分校化学系，博士后（合作导师：James Turkson教授，Marcus A Tius教授）
3、学术荣誉
2025/01，中国药科大学兴药领军学者计划
2015/11，16th Tetrahedron Symposium, Asian Edition, Elsevier Best Poster Prize
2015/10，NSFC-RSC International Symposium on Emerging Frontiers in Organic Synthesis, Royal Society of Chemistry Poster Prize
2012年，河南省优秀应届大中专毕业生
课题组主要从事生物催化和生物合成相关课题研究，具体研究兴趣包括：
1. 基于化学原理，设计改造非天然生物催化新体系；
2. 基于酶学机制，开发仿生催化和绿色合成；
3. 利用生物合成技术，开发高附加值医药化学品的高效生物制造。
课题组网页：
https://www.x-mol.com/groups/fu_wenzhen
1. 发展了一个高效的P450金属酶氧化还原催化平台，实现高活性自由基的不对称转化，用于开发非天然酶促反应，实现了碳自由基对不饱和芳香体系的不对称加成和去芳构化。
2. 已申请专利：
(4) Yang, Y.; Fu, W.; Neris, N. M.; Zhao, Y. Compositions, Systems, and Methods for Biocatalytic Radical Addition to Aromatic Compounds. US Provisional Patent App. No. 63/477,081. UC Case No. 2023-854.
(3) Turkson, J.; Lopez-Tapia, F.; Tius, M.; Yue, P.; Brotherton-Pleiss, C.; Fu, W. Aryl Sulfonamides as Small Molecule Stat3 Inhibitors. WO2021016333A1, January 28, 2021.
(2) 汤文军, 付文振, 刘国都. 手性双膦配体、其制备方法、中间体及应用. CN109293700B, 2021-02-09.
(1) 汤文军, 付文振. 一种取代的2,3-二氢苯并[d][1,3]氧杂磷杂茂配体的制备方法. CN104558038A, 2015-04-29.
1.Fu, Wenzhen; Fu, Yue†; Zhao, Yunlong†; Wang, Huanan; Liu, Peng*; Yang, Yang*, A general metalloenzyme platform for catalytic asymmetric radical dearomatisation. Nat. Chem. 2024, 16 (12), 1999–2008. (IF: 19.2)
2.Fu, Wenzhen; Neris, Natalia M.; Fu, Yue; Zhao, Yunlong; Krohn-Hansen, Benjamin; Liu, Peng*; Yang, Yang*, Enzyme-Controlled Stereoselective Radical Cyclisation to Arenes Enabled by Metalloredox Biocatalysis. Nat. Catal. 2023, 6 (7), 628–636. (IF: 42.9)
3.Chen, Heyu†; Fu, Wenzhen†; Yang, Yang*, P450-Catalyzed Atom Transfer Radical Cyclization. In Methods in Enzymology; Academic Press, 2023. (†Contributed equally, IF: 1.68)
4.Fu, Wenzhen; Yang, Yang*, Undirected Biocatalytic Amination of Unactivated C(Sp3)−H Bonds. Chem. Catal. 2022, 2 (12), 3287–3289. (Invited Preview, IF: 10.8)
5.Fu, Wenzhen; Tang, Wenjun*, Chiral Monophosphorus Ligands for Asymmetric Catalytic Reactions. ACS Catal. 2016, 6 (8), 4814–4858. (Review, IF: 10.614)
6.Fu, Wenzhen; Nie, Ming; Wang, Aizhen; Cao, Ziping; Tang, Wenjun*, Highly Enantioselective Nickel-Catalyzed Intramolecular Reductive Cyclization of Alkynones. Angew. Chem. Int. Ed. 2015, 54 (8), 2520–2524. (IF: 11.709)
7.Yue, Peibin; Zhu, Yinsong; Brotherton-Pleiss, Christine; Fu, Wenzhen; Verma, Nagendra; Chen, Jasmine; Nakamura, Kayo; Chen, Weiliang; Chen, Yue; Alonso-Valenteen, Felix; Mikhael, Simoun; Medina-Kauwe, Lali; Kershaw, Kathleen M.; Celeridad, Maria; Pan, Songqin; Limpert, Allison S.; Sheffler, Douglas J.; Cosford, Nicholas D. P.; Shiao, Stephen L.; Tius, Marcus A.; Lopez-Tapia, Francisco*; Turkson, James*, Novel Potent Azetidine-Based Compounds Irreversibly Inhibit Stat3 Activation and Induce Antitumor Response against Human Breast Tumor Growth in Vivo. Cancer Lett. 2022, 534, 215613. (IF: 9.7)
8.Brotherton-Pleiss, Christine; Yue, Peibin; Zhu, Yinsong; Nakamura, Kayo; Chen, Weiliang; Fu, Wenzhen; Kubota, Casie; Chen, Jasmine; Alonso-Valenteen, Felix; Mikhael, Simoun; Medina-Kauwe, Lali; Tius, Marcus A.; Lopez-Tapia, Francisco*; Turkson, James*, Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors. J. Med. Chem. 2021, 64 (1), 695–710. (IF: 8.039)
9.Liu, Guodu; Fu, Wenzhen; Mu, Xingye; Wu, Ting; Nie, Ming; Li, Kaidi; Xu, Xiaodong; Tang, Wenjun*, Pyrrolidines and Piperidines Bearing Chiral Tertiary Alcohols by Nickel-Catalyzed Enantioselective Reductive Cyclization of N-Alkynones. Commun. Chem. 2018, 1 (1), 90. (IF: 4.253)
10.Fu, Wenzhen; Wu, Di; Zhang, Zhenhua; Huang, Lin; Niu, Yunyin*, C–C Oxidative Coupling Reaction of Ethylene-Bridged Azoles via Double C–H Activation With the Catalyst CuX (X = I, Br). Synth. React. Inorg. Met.-Org. Nano-Met. Chem. 2012, 42 (6), 878–881. (IF: 0.521)
11.Fu, Wenzhen; Wang, Hanqi; Wang, Bei; Duan, Haojie; Cui, Xinxin; Wang, Weijuan; Wang, Zheguang; Zhang, Zhenhua; Liu, Xiucun; Niu, Yunyin*, Syntheses and Crystal Structures of Four Supramolecular Halides/Pseudohalides: [(ZnCl4)(BPX)], [(CdCl4)(BPX)], [(HgCl4)(BPX)], and [Cu4(SCN)6(BPX)]n Directed by 1,4-Bis(Pyridinium)Xylol Cations. Synth. React. Inorg. Met.-Org. Nano-Met. Chem. 2011, 41 (3), 272–278. (IF: 0.467)
