(1) 高分子化学
(2) 主族化学
(3) 光动力治疗

1、科研项目
（1）江苏省特聘教授，省级项目，高纯度多功能有机硅材料的可控合成及应用研究，2025 至 2028，在研，主持
（2）中国药科大学，兴药领军学者A类， 2025，在研，主持。
2、代表性科研成果
(1) 在低聚环氧硅烷的开环聚合领域：1. 开发了新型智能自淬灭系统， 60年来首次证明低聚环氧硅烷的完全开环聚合是可以实现的；2. 设计了多功能卡宾催化剂，实现了开环聚合与缩聚协同反应，直接制得高纯度、分子量可控的均聚及嵌段共聚物，具有重要应用前景；3. 针对工业生产中复杂的工艺与高昂的成本等问题，成功设计并制备了价格低廉的多功能催化剂，实现“一锅法”合成各类高纯度有机硅。该催化剂在 Elkem 公司中试，具备产业化应用潜力。(国际专利号：PCT/FR2024/000037, PCT/FR2024/000061和PCT/FR2024/000071)
(2) 在化学和药学的交叉领域：通过对外围基团的精准控制，合成了一系列卟啉超分子光敏剂，显著提高了双光子性质，荧光和氧光敏化能力(Chem. Eur. J., 2024, e202303243)；对卟啉分子的亲水性-疏水性平衡、内在化能力和生物介质中的聚集等因素控制，使光动力治疗的效果明显增强(Chem Commun., 2019, 55, 12231-12234)；申请人将疏水性卟啉负载到水溶性聚合物中，在光动力治疗方面也获得了良好的结果(Cancers, 2022, 14, 2358)。

(1) Limiao Shi, Shushen Chi, Viktoriia Gorbunova, Nicolas Richy, Mireille Blanchard-Desce, Olivier Mongin, Frédéric Paul, Christine O. Paul-Roth*, Star-Shaped Fluorescent Porphyrins with Impressive Two-Photon-Absorption Cross-Sections for Oxygen Sensitization: The Impact of Periphery-Conjugated Electron-Releasing Groups, Chemphotochem, 2025, 2500086. (IF:3.0)
(2) Limiao Shi, Zhipeng Sun, Nicolas Richy, Mireille Blanchard-Desce, Olivier Mongin, Frédéric Paul, Christine O. Paul-Roth*, Giant Star-shaped meso-substituted Fluorescent Porphyrins with Fluorenyl-containing Arms Designed for Two-photon Oxygen Photosensitization, Chem. Eur. J., 2024, 30, e202303243. (IF:4.0)
(3) Limiao Shi, Aurelie Boulegue-Mondiere, Delphine Blanc, Antoine Baceiredo, Vicenç Branchadell, Tsuyoshi Kato*, Ring opening polymerization of cyclic oligosiloxanes without producing cyclic oligomers, Science, 2023, 381, 1011-1014. (IF:56.9).
(4) Aymeric Dajnak, Limiao Shi, Gül Altınbaş Özpınar, Romaric Lenk, Nathalie Saffon-Merceron, Antoine Baceiredo, Tsuyoshi Kato, Thomas Müller, Eddy Maerten*, Imine-Stabilized Silylium Ions: Synthesis, Structure and Application in Catalysis, Dalton Trans., 2023, 52, 3052-3058. (IF:4.0)
(5) Limiao Shi, Christophe Nguyen, Morgane Daurat, Nicolas Richy, Corentin Gauthier, Estelle Rebecq, Magali Gary-Bobo, Sandrine Cammas-Marion*, Olivier Mongin, Christine O. Paul-Roth*, Frédéric Paul*, Encapsulation of hydrophobic porphyrins into biocompatible nanoparticles: an easy way to benefit of their two-photon phototherapeutic effect without hydrophilic functionalization, Cancers, 2022, 14(10), 2358. (IF:6.58).
(6) Xu Zhang, Limiao Shi, Mark A. Fox, Adam Barlow, Mahbod Morshedi, Marie P. Cifuentes, Mark G. Humphrey, Olivier Mongin, Frédéric Paul, Christine O. Paul Roth*, Nonlinear optical properties of meso-Tetra(fluorenyl)porphyrins peripherally functionalized with one to four ruthenium alkynyl substituents, Dyes and Pigments, 2021, 188, 109155. (IF:5.12)
(7) Limiao Shi, Christophe Nguyen, Morgane Daurat, Abdelhamid Chiheb Dhieb, Wajda Smirani, Mireille Blanchard-Desce, Magali Gary-Bobo*, Olivier Mongin*, Christine Paul-Roth*, Frédéric Paul, Biocompatible Conjugated Fluorenylporphyrins for Two-photon Photodynamic Therapy and Fluorescence Imaging, Chemical Communications, 2019, 55, 12231-12234. (IF:6.16).
(8) BOULEGUE MONDIERE Aurélie; BLANC Delphine; PARISOT Hervé; KATO Tsuyoshi; SHI Limiao; BACEIREDO Antoine ; Procédé de polymérisation par ouverture de cycle ou par polycondensation, 2025-1-16, WIPO, PCT/FR2024/000071 (国际专利)
(9) BOULEGUE MONDIERE Aurélie; BLANC Delphine; PARISOT Hervé; KATO Tsuyoshi; SHI Limiao; BACEIREDO Antoine ; Procédé de polymérisation par ouverture de cycle ou par polycondensation, 2024-12-12, WIPO, PCT/ FR2024/000061 (国际专利)
(10) BOULEGUE MONDIERE Aurélie; BLANC Delphine; BACEIREDO Antoine; KATO Tsuyoshi; SHI Limiao; Méthode de polymérisation par ouverture de cycle, 2024-10-3, WIPO, PCT/FR2024/000037 (国际专利)