1.单细胞生物大分子（蛋白质、RNA及其修饰）原位多重成像新技术
2.核酸信号放大辅助的分子诊断（基因突变、病原体核酸）新技术

（1）国家自然科学基金，青年项目，2025.1-2027.12，30万元，在研，主持
（2）江苏省自然科学基金，青年项目，2024.09-2027.08，20万元，在研，主持

1. C. Wang#*, J. Zheng#, Z. Xiong#, W. Yin, Y. Zhao, H. Wu, S. Liang, L. Zhang, C. Yao, Z. Deng, Y. Liu, Q. Song*, G. Zhou*, B. Zou*. Voltage-programmed sequential fluorescence encoding (VPSFE) enables multiplexed in situ proteo-imaging with electric-field turing patterns. Angew Chem Int Ed Engl. 2025, e202511629. doi:10.1002/anie.202511629 (IF: 16.9)
2. Z. Zhang, Y. Yuan, T. Hu, M. Wang, W. Zhang, Y. Nie, S. Liang, Q. Song*, C. Wang*, B. Zou*. Proximity cleavage assay (PCA): A single-step, 20-minute platform for protein detection in 1-μL biofluids. Biosens Bioelectron. 2025, 289: 117864. (IF: 10.5)
3. C. Wang#, C. Wang#, C. Xiao, W. Zhang, Y. Guo, M. Qu, Q. Song*, X. Qi*, B. Zou*. Tumor-selective gene therapy: using hairpin DNA oligonucleotides to trigger cleavage of target RNA by endogenous flap endonuclease 1 (FEN 1) highly expressed in tumor cells. Small. 2025, 21(20): e2410146. (IF: 12.1)
4. Z. Zhang, M. Wang, T. Hu, Y. Yuan, Y. Zhang, Q. Song*, C. Wang*, B. Zou*. An AND-gate DNA walker sensing microRNA and flap endonuclease 1. Microchim Acta. 2025,192(9): 615. (IF: 5.3)
5. C. Wang, Z. Zhang, Y. Qiu, Y. Bao, Q. Song*, B. Zou*. In situ track-generated DNA walker for AND-gate logic imaging of telomerase and flap endonuclease 1 activities in living cells. Anal Chem. 2024, 96(2): 756-765. (IF: 7.4)
6. Z. Xiang#, J. Zheng#, X. Ma, Y. Chu, Q. Song, G. Zhou, B. Zou*, H. Wu*, C. Wang*. FEN1-assisted DNA logic amplifier circuit for fast and compact DNA computing. Chem Comm. 2024, 60(34): 4593-4596. (IF: 4.3)
7. C. Wang#, J. Wang#, X. Xue, Y. Shen, B. Zou, S. Wang*, Q. Song*, G. Zhou. An alternative low-cost strategy for simultaneous sensitive detection of adjacent ESR1 mutations in single circulating tumor cell. J Anal Test. 2023, 7, 89-100. (IF: 7.0)
8. C. Wang, D. Hao, Y. Bao, X. Xu, Y. Li, B. Zou*, L. Ding*, Q. Song*. A DNA nano firework for imaging and inhibitor screening of flap endonuclease 1 in living cells. Anal Chem. 2023, 95(22): 8621-8631. (IF: 7.4)
9. C. Wang#, H. Zeng#, L. Zhang, Y. Shen, B. Zou, S. Wang*, Q. Song*, G. Zhou. Sensitive quantitation of ESR1 mutations in cell-free DNA from breast cancer patients using base-specific invasive reaction assisted qPCR. J Pharm Biomed Anal. 2021, 197: 113959. (IF: 3.209)
10. J. Weng, N. Sheng, R. Wang, S. Liang, C. Wang, X. Bai, G. Zhou*, B. Zou*, Q. Song*. Multiplex visualized closed-tube PCR with hamming distance 2 code for 15 HPV subtype typing. Anal Chem. 2021, 93(13): 5529-5536. (IF: 8.008)

邹秉杰 教授
宋沁馨 教授