肠道炎症、感染相关疾病的发病机制及预防治疗策略
1. 肠道病原体感染过程中病原体、肠道微生物群及宿主免疫系统之间的互作机制
2. 炎症性肠病治病机理及免疫治疗新靶点挖掘
3. 母乳中免疫组分在维持婴幼儿肠道健康中的作用

1、科研项目
（1）国家自然科学基金高层次青年人才项目，主持
（2）中国药科大学兴药领军学者A类启动经费，主持
（3）国家自然科学基金青年科学基金项目C类，主持
2、代表性科研成果
（1）首次揭示了母乳中补体成分的关键作用，发现补体成分通过调控婴幼儿肠道微生物而影响后代肠道健康，开辟了母乳中补体生理学功能这一全新领域。
（2）阐明Citrobacter rodentium感染小鼠诱导结肠炎过程中细菌不同毒力因子的功能及其在感染过程中的作用。

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