（1）拟肽药物的设计与合成
（2）人工智能驱动的拟肽药物设计与发现
（3）生物医用高分子材料的设计与合成

国家自然科学基金青年基金项目
江苏省自然科学基金青年基金项目
江苏省双创博士

1. Jiang, W.*; Chen, J.*; Wang, H.; Xue, A.; Zhang, X.; Guan, J.; Wei, L.; Cai, J.*; Hu, Y.*; Liu, D. *Design, Synthesis and Pharmacological Evaluation of Novel 4-Phenoxyquinoline Derivatives as VEGFR2 Kinase Inhibitors for Tumor Treatment. Chem. Res. Chin. Univ. 2025, 41, 66-78. (IF: 3.0)
2. Jiang, W.*; Abdulkadir, S.*; Zhao, X.*; Sang, P.; Tomatsidou, A.; Zhang, X.; Chen, Y.; Calcul, L.; Sun, X.; Cheng, F.*; Hu, Y.*; Cai, J.*Inhibition of hypoxia-inducible transcription factor (HIF-1α) signaling with sulfonyl-γ-AApeptide helices. J. Am. Chem. Soc. 2023, 145, 20009-20020. (IF: 15.0)
3. Jiang, W.; Tie, Z.; Yu, C.; Chen, Y.; Liu, D.*; Li, B.* An engineered nanoplatform inhibiting energy metabolism and lysosomal activity of tumor cells to multiply cisplatin-based chemotherapy. Biomaterials 2023, 302, 122354. (IF: 14.0)
4. Jiang, W.; Wei, L.; Chen, B.; Luo, X.; Xu, P.*; Cai, J.*; Hu, Y.* Platinum prodrug nanoparticles inhibiting tumor recurrence and metastasis by concurrent chemoradiotherapy. J. Nanobiotechnol. 2022, 20, 129. (IF: 9.4)
5. Abdulkadir, S.*; Li, C.*; Jiang, W.*; Zhao, X.; Sang, P.; Wei, L.; Hu, Y.*; Li, Q.*; Cai, J. *Modulating angiogenesis by proteomimetics of vascular endothelial growth factor. J. Am. Chem. Soc. 2021, 144, 270-281. (IF: 15.4)
6. Jiang, W.; Luo, X.; Wei, L.; Yuan, S.; Cai, J.*; Jiang, X.*; Hu, Y.* The sustainability of energy conversion inhibition for tumor ferroptosis therapy and chemotherapy. Small 2021, 17, 2102695. (IF: 13.3)
7. Jiang, W.; Han, X.; Zhang, T.; Xie, D.; Zhang, H.*; Hu, Y. *An Oxygen Self‐Evolving, Multistage Delivery System for Deeply Located Hypoxic Tumor Treatment. Adv. Healthcare Mater. 2020, 9, 1901303. (IF: 7.4)
8. Jiang, W.; Zhang, C.; Ahmed, A.; Zhao, Y.; Deng, Y.; Ding, Y.*; Cai, J.*; Hu, Y.* H2O2‐sensitive upconversion nanocluster bomb for tri‐mode imaging‐guided photodynamic therapy in deep tumor tissue. Adv. Healthcare Mater. 2019, 8, 1900972. (IF: 6.3)