(1) 神经退行性疾病中的蛋白质量控制系统机制研究
(2) 炎性疼痛的分子机制研究

1、科研项目
（1）国家自然科学基金委员会, 青年科学基金项目(C类)[原青年科学基金项目], 32100771, SAP102 Ser-386磷酸化对突触功能的调控及其在炎性疼痛中的作用, 2022-01-01 至 2024-12-31, 30万元, 结题, 主持
（2）中国药科大学，兴药领军学者A类， 2026，在研，主持。
2、代表性科研成果
(1) 在神经退行性疾病领域：1. 首次揭示TRIM11蛋白在阿尔茨海默病（AD）等tau蛋白病中的关键保护作用，发现其在AD患者脑中显著下调； 2.阐明TRIM11通过促进tau蛋白降解、抑制其错误折叠及溶解已形成纤维三种机制，发挥对抗tau毒性的功能； 3. 通过动物实验验证，补充TRIM11可有效改善tau病理、减轻神经炎症并恢复认知功能，证实其作为治疗靶点的潜力 (Science, 2023, 381)。
(2) 在炎性疼痛领域：1. 首次发现E3泛素连接酶Cbl-b通过泛素化调控GluN2B-NMDAR的发育性突触移除，而炎症通过抑制Cbl-b功能导致GluN2B重新聚集于突触，从而增强疼痛（Sci Signal, 2020, 13）；2.首次揭示脊髓背角的甘氨酸受体α1ins变体通过mGluR5-ERK信号通路被磷酸化和泛素化，进而被内吞，从而解除其对疼痛信号的抑制，参与病理性疼痛的发生（PLoS Biol, 2019, 17）。

(1) Zhang, Z.Y; Harischandra, Dilshan S.; Wang, R.F; Ghaisas, Shivani; Zhao, Janet Y.; McMonagle, Thomas P.; Zhu, G.X; Lacuarta, Kenzo D.; Song, J.N; Trojanowski, John Q.; Xu, H; Lee, Virginia M. Y.; Yang, Xiaolu ; TRIM11 protects against tauopathies and is down-regulated in Alzheimer's disease, SCIENCE, 2023, 381(6656) (IF:63.7)
(2) Zhang, Z. Y; Bai, H. H; Guo, Z; Li, H. L; Diao, X. T; Zhang, T. Y; Yao, L; Ma, J. J; Cao, Z; Li, Y. X; Bai, X; Chen, H. K; Suo, Z. W; Yang, X; Hu, X. D. ; Ubiquitination and functional modification of GluN2B subunit-containing NMDA receptors by Cbl-b in the spinal cord dorsal horn, Sci Signal, 2020, 13(638) (IF:8.2)
(3) Zhang, Z. Y; Bai, H. H; Guo, Z; Li, H. L; He, Y. T; Duan, X. L; Suo, Z. W; Yang, X; He, Y. X; Hu, X. D; mGluR5/ERK signaling regulated the phosphorylation and function of glycine receptor alpha1ins subunit in spinal dorsal horn of mice, PLoS Biol, 2019, 17(8) (IF:7.1)
(4) Zhang, Z. Y; Guo, Z; Li, H. L; He, Y. T; Duan, X. L; Suo, Z. W; Yang, X; Hu, X. D. ; Ubiquitination and inhibition of glycine receptor by HUWE1 in spinal cord dorsal horn, Neuropharmacology, 2019, 148: 358-365 (IF:7.1)
(5) Gidado, Khalid Idris; Adeshakin, Funmilayo O.; Rabiu, Lawan; Zhang, Z.Y; Zhang, G.Z; Wan, X.C ; Multifaceted roles of DLG3/SAP102 in neurophysiology, neurological disorders and tumorigenesis, NEUROSCIENCE, 2025, 565: 192-201 (IF:2.8)
(6) Zhang, Z. Y; Guo, Z; Li, H. L; He, Y. T; Duan, X. L; Suo, Z. W; Yang, X; Hu, X. D. ; Ubiquitination and inhibition of glycine receptor by HUWE1 in spinal cord dorsal horn, Neuropharmacology, 2019, 148: 358-365 (IF:4.4)
(7) Hu, X. D; Liu, Y. N; Zhang, Z. Y; Ma, Z. A; Suo, Z. W; Yang, X; Spinophilin-Targeted Protein Phosphatase-1 Alleviated Inflammatory Pain by Negative Control of MEK/ERK Signaling in Spinal Cord Dorsal Horn of Rats, Journal of Neuroscience, 2015, 35(41): 13989-4001 (IF:5.9)
(8) Yang, L; Bai, H. H; Zhang, Z. Y; Liu, J. P; Suo, Z. W; Yang, X; Hu, X. D. ; Disruption of SHP1/NMDA receptor signaling in spinal cord dorsal horn alleviated inflammatory pain, Neuropharmacology, 2018, 137: 104-113 (IF:4.3)
(9) Wang, X. T; Zheng, R; Suo, Z. W; Liu, Y. N; Zhang, Z. Y; Ma, Z. A; Xue, Y; Xue, M; Yang, X; Hu, X. D. ; Activity-dependent dephosphorylation of paxillin contributed to nociceptive plasticity in spinal cord dorsal horn, Pain, 2016, 157(3): 652-665
(10) Wang, W. T; Pan, G. Q; Zhang, Z. Y; Suo, Z. W; Yang, X; Hu, X. D. ; Ht31 peptide inhibited inflammatory pain by blocking NMDA receptor-mediated nociceptive transmission in spinal dorsal horn of mice, Neuropharmacology, 2015, 89: 290-7 (IF:5.1)