复杂活性多肽的全合成、修饰及药物化学研究

1、科研项目
（1）中国博士后基金，面上项目，2023-2025，已结题，主持。
（2）国家自然科学基金委，青年项目，2024-2026，在研，主持。
（3）中国药科大学高层次人才启动经费，2026 至 2032，200万，在研，主持。
2、学术获奖
2018中国科学院朱李月华奖学金 2020 国家奖学金 2022 中国科学院朱李月华奖学金 2022 北京市优秀毕业生 2022 中国科学院优秀毕业生 3、代表性科研成果
(1) 首次实现细胞松弛素单体的规模化全合成（Angew. Chem. Int. Ed. 2018, 57, 14221-14224），发展集群式全合成策略，首次完成数十个细胞松弛素多聚体天然产物的全合成（Chem 2021, 7, 212-223），系统解决了多聚体结构多样、合成难度极高的问题，为其构效关系研究与药用开发奠定了关键合成基础。
(2) 完成具有抗炎活性的螺环三萜spirochensilide A简洁全合成（J. Am. Chem. Soc. 2022, 144, 16292-16297.），为炎症疾病研究提供关键探针。
(3) 首次实现对大豆胞囊线虫有极强诱导活性的glycinoeclepin A仿生合成（J. Am. Chem. Soc. 2026, 投稿中），为农业线虫防治提供物质支撑，助力天然产物药用与农用潜力开发。

(1) Xianwen Long†, Zhilong Feng†, Yaqiu Zhao†, Tao Zhang, Jie Chen, Jun Li, Huimin Huang, Luhua Wang, Luqi Huang,* Jun Deng*. Bioinspired Synthesis of Glycinoeclepin A from γ-Oryzanol Enabled by Programmed Skeletal Reorganization J. Am. Chem. Soc., 2026, submitted
(2) Yiming Ding†, Xianwen Long†, Jingwei Zhang, Chunlei Qu, Peng Wang, Xiaodong Yang, Pema-Tenzin Puno and Jun Deng*, Asymmetric Total Synthesis of Penicifuranone A through NHC-Catalyzed Umpolung. Chem. Sci., 2025, 16, 8302-8308. (Hot Paper, IF = 7.4)
(3) Xianwen Long†, Jun Li†, Feng Gao, Hai Wu and Jun Deng*, Bioinspired Synthesis of Spirochensilide A from Lanosterol. J. Am. Chem. Soc. 2022, 144, 16292-16297. ("Most Read Articles" of the month, IF = 15.0).
(4) Xianwen Long，Min Zhang, Xiaodong Yang and Jun Deng*, Total Synthesis of (±)-Spiroaxillarone A via a Reversible Sulfa-Michael Addition. Org. Lett. 2022, 24, 1303−1307. (Cover Picture, IF = 5.36).
(5) Yonglong Zhao, Xianwen Long, Hai Wu and Jun Deng*, Recent Advances of Cytochalasans Natural Products Total Synthesis Using Bioinspired Strategies. Org. Chem. Front. 2022, 9, 6979-6998. (Invited review, IF = 5.4)
(6) Xianwen Long†, Hai Wu†, Yiming Ding, Chunlei Qu and Jun Deng*, Biosynthetically Inspired Divergent Syntheses of Merocytochalasans. Chem. 2021, 7, 212-223. (IF = 22.8)
(7) Hai Wu†, Yiming Ding†, Kun Hu†, Xianwen Long, Chunlei Qu, Pema-Tenzin Puno* and Jun Deng*, Bioinspired Network Analysis Enabled Divergent Syntheses and Structure Revision of Pentacyclic Cytochalasans. Angew. Chem. Int. Ed. 2021, 60, 15963-15971. (IF = 16.8)
(8) Chunlei Qu†, Xianwen Long†, Yueqian Sang, Min Zhang, Xiaoli Zhao, Xiao-Song Xue* and Jun Deng*, Biomimetic Total Synthesis of (±)-Carbocyclinone-534 Reveals Its Biosynthetic Pathway. Org. Lett. 2020, 22, 9421-9426. (Cover Picture. IF = 6.09)
(9) Xianwen Long†, Yiming Ding† and Jun Deng*, Total Synthesis of Asperchalasines A, D, E, and H. Angew. Chem. Int. Ed. 2018, 57, 14221-14224. (Highlighted by Synfacts, Org. Chem. and Chin. J. Org. Chem. IF = 12.25)
(10) Xianwen Long, Yunhong Huang, Yang Long and Jun Deng*. Biomimetic total synthesis of homodimericin A. Org. Chem. Front. 2018, 5, 1152-1154. (IF = 5.07)