(1) 口服药物递送系统开发及其免疫调控研究；
(2) 肿瘤疫苗的开发。

1、科研项目
（1）国家自然科学基金委员会，青年科学基金项目，51603080，肿瘤细胞/亚细胞器双靶向多肽药物载体的设计及其在抑制肿瘤耐药性中的研究,，2017/01至2019/12，结题，主持
（2）国家自然科学基金委员会，面上项目，21778020，狂犬病病毒脑内分布的三维成像分析及其光热清除策略研究，2018/01至2021/12，结题，参与
2、代表性科研成果
（1）研发结肠滞留性菊粉水凝胶，调控肠道菌群及代谢物，增强免疫检查点抑制剂抗体疗效，并降低其肠道毒性
（2）研发菊粉水凝胶/过敏原蛋白质口服递送系统，提高蛋白质药物在病灶处滞留，同时调控回肠菌群及其代谢物，诱导免疫耐受环境，实现食物过敏长效治疗
（3）研发系列多肽微粒药物递送系统，实现药物分子增效减毒

1. K Han^†, J Xu^†, F Xie^†, J Crowther, JJ Moon^*, Engineering strategies to modulate the gut microbiome and immune system, J. Immunol. 2024, 212: 208.
2. K Han^†, YS Cho^†, JJ Moon^*, Antibiotic nanoparticles boost antitumor immunity, Nat. Biotechnol. 2023, doi.org/10.1038/s41587-023-02046-6.
3. K Han, J Nam, J Xu, X Sun, XH Huang, O Animasahun, A Achreja, JH Jeon, B Pursley, N Kamada, GY Chen, D Nagrath, JJ Moon^*, Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel, Nat. Biomed. Eng. 2021, 5: 1377.
4. ZY Ma, K Han^*, XX Dai, HY Han^*, Precisely striking tumor without adjacent normal tissue damage via mitochondria-templated accumulation, ACS Nano 2018, 12: 6252.
5. XX Dai^†, K Han^†,*, ZY Ma, HY Han^*, A chimeric peptide logic gate for orthogonal stimuli-triggered precise tumor therapy, Adv. Funct. Mater. 2018, 28: 1804609.
6. K Han, J Zhang, WY Zhang, SB Wang, LM Xu, C Zhang, XZ Zhang, HY Han^*, Tumor-triggered geometrical shape switch of chimeric peptide for enhanced in vivo tumor internalization and photodynamic therapy, ACS Nano 2017, 11: 3178.
7. K Han, WY Zhang, J Zhang, Q Lei, SB Wang, JW Liu, XZ Zhang, HY Han^*, Acidity-triggered tumor-targeted chimeric peptide for enhanced intra-nuclear photodynamic therapy, Adv. Funct. Mater. 2016, 26: 4351.
8. K Han^†, SB Wang^†, Q Lei, JY Zhu, XZ Zhang^*, Ratiometric biosensor for aggregation-induced emission-guided precise photodynamic therapy, ACS Nano 2015, 9: 10268.

研究团队
博士研究生：吴宛涛（2023级）
硕士研究生：胡冰雨（2023级）、凌超群（2023级）